At the Kendall Lab, associated with the Department of Microbiology, Immunology, and Cancer Biology (MIC), we are interested in mechanisms that bacterial pathogens use to integrate host- and bacterial-derived signals to sense their environment, coordinate gene expression, and cause disease.
We study these processes in the intestinal pathogens enterohemorrhagic E. coli O157:H7, Salmonella enterica, and Citrobacter rodentium. Our projects involve a mix of experimental approaches, ranging from genetics, biochemistry, microscopy, and bioinformatics.
How Salmonella Defeats Immune System
In a surprising new discovery about potentially deadly salmonella, researchers have determined that the foodborne bacteria has a most unexpected way of telling where it is in the body: It uses its food as its GPS. Watch Video
Salmonella Strategies for Host Adaptation
Understanding bacterial adaptation strategies helps us provide new therapeutic intervention strategies. Read More
‘Trail of Bread Crumbs’ Map for Pathogens
Microbiota release nutrients which provide spatial information to pathogens, giving them a map to the intestinal landscape. Read More