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Zong Lab

Publications

Research papers

  • Zeng J, Alvarez-Yela AC, Casarez E, Jiang Y, Wang L, Kelly BE, Ke E, Jenkins T, Atkins KA, Janes KA, Slack-Davis JK*, Zong H* (2023) Dichotomous ovarian cancer-initiating potential of Pax8+ cells revealed by a mouse genetic mosaic model. iScience, 26(5) 106742. PMC10189502
  • Xu B*, Kucenas S, Zong H* (2022) zMADM (zebrafish Mosaic Analysis with Double Markers) for single-cell gene knockout and dual lineage tracing. PNAS, 119(9):e2122529119. PMC8892518
  • Sutcliffe MD, Galvao RP, Wang L, Kim J, Rosenfeld LK, Singh S, Zong H*, Janes KA* (2021) Premalignant oligodendrocyte precursor cells stall in a heterogeneous state of replication stress prior to gliomagenesis. Cancer Research, 81(7):1868-1882. PMC8137536
  • Yao M., Ventura P. B., Jiang Y., Rodriguez F. J., Wang L., Perry J. S. A., Yang Y., Wahl K., Crittenden R. B., Bennett M. L., Qi L., Gong C. C., Li X. N., Barres B. A., Bender T. P., Ravichandran K. S., Janes K. A., Eberhart C. G., Zong H., Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth, 2020; Cell. 180(3) 502-520. PMID: 31983537 | PMCID: PMC7259679
  • Terry T. T., Cheng T., Mahjoub M., Zong H., Mosaic Analysis with Double Markers reveals IGF1R function in granule cell progenitors during cerebellar development, 2020; Dev Biol. 465(2) 130-143. PMID: 32697974 | PMCID: PMC7494377
  • Gonzalez PP, Kim J, Galvao RP, Cruickshanks N, Abounader R, Zong H, p53 and NF 1 loss plays distinct but complementary roles in glioma initiation and progression., 2018; Glia. 66(5) 999-1015. PMID: 29392777
  • Ledur PF, Liu C, He H, Harris AR, Minussi DC, Zhou HY, Shaffrey ME, Asthagiri A, Lopes MB, Schiff D, Lu YC, Mandell JW, Lenz G, Zong H, Culture conditions tailored to the cell of origin are critical for maintaining native properties and tumorigenicity of glioma cells., 2016; Neuro-oncology. 18(10) 1413-24. PMID: 27106408 | PMCID: PMC5035523
  • Galvao, R.P., Kasina, A., McNeill, R.S., Harbin, J.E., Foreman, O., Verhaak, R.G.W., Nishiyama, A., Miller, C.R., Zong, H. (2014) Transformation of quiescent adult oligodendrocyte precursor cells into malignant glioma through a multi-step reactivation process. PNAS, 111(40):E4214-23
  • Henner A, Ventura PB, Jiang Y, Zong H. 2013 MADM-ML, a Mouse Genetic Mosaic System with Increased Clonal Efficiency. PMID: 24143253 PuBMed
  • Liu, C., Sage, J.C., Miller, M.R., Verhaak, R.G.W., Hippenmeyer, S., Vogel, H., Foreman, O., Bronson, R.T., Nishiyama, A., Luo, L., Zong, H.* (2011) Mosaic Analysis with Double Markers Reveals Tumor Cell-of-Origin in Glioma. Cell , 146:209-221 PubMed PMC
  • Muzumdar, M.D.*, Luo, L., Zong, H.* (2007) Modeling sporadic loss of heterozygosity in mice by using mosaic analysis with double markers (MADM). PNAS, 104:4495-4500 PubMed PMC
  • Zong, H., Espinosa, S., Su, H., Muzumdar, M.D., and Luo, L. (2005) Mosaic analysis with double markers in mice. Cell, 121:479-492 PubMed
  • Luo, L., Zong, H. (2001) Single neuron labeling and genetic manipulation. Nature Neuroscience, 4:1158-1159 PubMed
  • Zong, H., Kaibuchi, K., Quilliam, L.A. (2001) The “Insert region” of RhoA is essential for Rho kinase activation and cellular transformation. Molecular and Cellular Biology, 21: 5287–5298 PubMed PMC
  • Zong, H., Raman, N., Mickelson-Young, L.A., Atkinson, S.J., Quilliam, L.A. (1999) Loop 6 of RhoA Confers Specificity for Effector Binding, Stress Fiber Formation, and Cellular Transformation. Journal of Biological Chemistry, 274:4551-4560 PubMed

Reviews & book chapters

  • Ledur PF, Onzi GR, Zong H, Lenz G, Culture conditions defining glioblastoma cells behavior: what is the impact for novel discoveries?, 2017; Oncotarget. 8(40) 69185-69197. PMID: 28978189 | PMCID: PMC5620329
  • Zong, H.*, Parada, L.F., Baker, S.J. (2014) Cell of origin for malignant gliomas and its implication in therapeutic development. Chapter in CSHL Perspectives, Glia. Ben Barres, Marc Freeman, Beth Stevens (Eds.) CSHL press http://cshperspectives.cshlp.org/cgi/reprint/cshperspect.a020610v1.pdf?ijkey=y2sBgBozbEQHgvv&keytype=finite
  • Zong, H. (2014) Generation and applications of MADM-based mouse genetic mosaic system. Chapter in Mouse Genetics. Methods in Molecular Biology Series, Vol. 1194:187-201. Shree Ram Singh, Vincenzo Coppola (Eds.) Humana Press and Springer
  • Galvão RP, Zong H. (2013) Inflammation and Gliomagenesis: Bi-Directional Communication at Early and Late Stages of Tumor Progression. PubMed PMC3607461[Available on 2014/3/1]
  • Liu, C., Zong, H. (2012) Developmental origins of brain tumors. Current Opinion in Neurobiology, 22(5):844-9 PubMed PMC
  • Zong, H.*, Verhaak, R.G.W., Canoll, P. (2012) The cellular origin for malignant glioma and prospects for clinical advancements. Expert Review of Molecular Diagnostics, 12(4):383-394 PubMed PMC

Collaborative papers

Brain tumor research

  • Jecrois ES, Zheng W, Bornhorst M, … Zong H, Packer RJ, Zhu Y (2021) Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors. Developmental Cell, doi: 10.1016/j.devcel.2021.08.004.• Jecrois ES, Zheng W, Bornhorst M, … Zong H, Packer RJ, Zhu Y (2021) Treatment during a developmental window prevents NF1-associated optic pathway gliomas by targeting Erk-dependent migrating glial progenitors. Developmental Cell, doi: 10.1016/j.devcel.2021.08.004.
  • Gao X, Zhang Z, Mashimo T, Shen B, Nyagilo J, Wang H, Wang Y, Liu Z, Mulgaonkar A, Hu XL, Piccirillo SGM, Eskiocak U, Davé DP, Qin S, Yang Y, Sun X, Fu YX, Zong H, Sun W, Bachoo RM, Ge WP. (2020) Gliomas Interact with Non-glioma Brain Cells via Extracellular Vesicles. Cell Reports, 30(8):2489-2500
  • Ohka F, Shinjo K, Deguchi S, Matsui Y, Okuno Y, Katsushima K, Suzuki M, Kato A, Ogiso N, Yamamichi A, Aoki K, Suzuki H, Sato S, Arul Rayan N, Prabhakar S, Göke J, Shimamura T, Maruyama R, Takahashi S, Suzumura A, Kimura H, Wakabayashi T, Zong H, Natsume A, Kondo Y. (2019) Pathogenic Epigenetic Consequences of Genetic Alterations in IDH-Wild-Type Diffuse Astrocytic Gliomas. Cancer Research, 79(19):4814-4827
  • Oncogenic effects of evolutionarily conserved noncoding RNA ECONEXIN on gliomagenesis S Deguchi, K Katsushima, A Hatanaka, K Shinjo, F Ohka, T Wakabayashi, … Oncogene 36 (32), 4629
  • Papagiannakopoulos, T., Friedmann-Morvinski, D., Neveu, P., Dugas, J.C., Gill, R.M., Huillard, E., Liu, C., Zong, H., Rowitch, D.H., Barres, B.A., Verma, I.M., Kosik, K.S. (2011) Pro-neuronal miR-128 is a glioma tumor suppressor that targets mitogenic kinases. Oncogene, 31(15):1884-1895 PubMed
Applications of the MADM system
  • Lineage-dependent spatial and functional organization of the mammalian enteric nervous system R Lasrado, W Boesmans, J Kleinjung, C Pin, D Bell, L Bhaw, S McCallum, …Science 356 (6339), 722-726
  • Ret and Etv4 promote directed movements of progenitor cells during renal branching morphogenesis P Riccio, C Cebrian, H Zong, S Hippenmeyer, F Costantini PLoS biology 14 (2), e1002382
  • Packard A, Georgas K, Michos O, Riccio P, Cebrian C, Combes AN, Ju A, Ferrer-Vaquer A, Hadjantonakis AK, Zong H, Little MH, Costantini F.(2013) Luminal Mitosis Drives Epithelial Cell Dispersal within the Branching Ureteric Bud. PubMed
  • Foo, L.C., Allen, N.J., Bushong, E.A., Ventura, P.B., Chung, W.S., Zhou, L., Cahoy, J.D., Daneman, R., Zong, H., Ellisman., M.H., Barres, B.A. (2011) Development of a Method for the Purification and Culture of Rodent Astrocytes. Neuron, 71:799-811 PubMed PMC
  • Hippenmeyer, S., Youn, Y.H., Moon, H.M., Miyamichi, K., Zong, H., Wynshaw-Boris, A., Luo, L. (2010) Genetic Mosaic Dissection of Lis1 and Ndel1 in Neuronal Migration. Neuron, 68:695-709 PubMed PMC
Development of genetic tools
  • Gay, L., Miller, M.R., Ventura, P.B., Devasthali, V., Vue, Z., Thompson, H.L., Temple, S., Zong, H., Cleary, M.D., Stankunas, K., Doe, C.Q. (2013) Mouse TU-tagging: a chemical/genetic intersectional method for purifying cell type specific nascent RNA. Genes and Development, 27:98–115 PubMed
  • Tasic, B., Miyamichi, K., Hippenmeyer, S., Sani, V.S., Zeng, H., Joo, W., Zong, H., Chen-Tsai, Y., Luo, L. (2012) Extensions of MADM (Mosaic Analysis with Double Markers) in Mice. PLoS One, 7(3):e33332 PubMed PMC
  • Tasic, B., Hippenmeyer, S., Wang, C., Gamboa, M., Zong, H., Chen-Tsai, Y., Luo, L. (2011) Site-specific integrase-mediated transgenesis in mice via pronuclear injection. PNAS, 108: 7902–7907 PubMed PMC

 

Selected Publications by Hui Zong

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Department of Microbiology, Immunology, and Cancer Biology