Zong Lab

To treat cancer effectively, Zong Lab has devoted great efforts to molecularly targeted therapy. While there have been many examples of success, cancer cells often develop drug resistance to evade therapy. To increase the efficacy of cancer therapy, Zong Lab–a part of the Department of Microbiology, Immunology and Cancer Biology (MIC)— uses a mouse genetic mosaic model termed MADM to study how tumor cells attack in vivo from the tumor-initiating stage and at the single-cell resolution. 

Cell of Origin and Disease

Identifying the cell(s) of origin should provide deep insights into leverage points for one to halt disease progression.
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A Multistep Reactivation Process

Since how malignant gliomas arise in the brain is a mystery, it is hindering the development of preventive and therapeutic interventions.
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Roles of p53 and NF 1 in Glioma

Malignant glioma is one of the deadliest types of cancer. Understanding how the cell origin progressively evolves toward malignancy could provide mechanistic insights and lead to novel concepts for tumor prevention and therapy.
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