The Microbial Pathogenesis group in the Department of Microbiology, Immunology, and Cancer Biology studies the molecular mechanisms of initiation and progression of infection by viral and bacterial pathogens.
Investigators in the Myles H. Thaler Center focus on the viral pathogens HIV, HTLV-1 and KSHV. Other viruses of departmental focus include herpes simplex virus, influenza, dengue, and Ebola.
The bacteriology group focus on intestinal infections caused by enterohemorrhagic Escherichia coli O157:H7, Salmonella typhimurium, Listeria monocytogenes and Shigella flexneri, as well as sexually transmitted infections caused by Neisseria gonorrhoeae and Chlamydia trachomatis.
Additional research in the department focuses on parasitic infections caused by Toxoplasma gondii.
The Microbial Pathogenesis faculty are affiliated with the Biomedical Sciences Graduate Program in the research disciplines of Microbiology, and Infectious Diseases and Biodefense and are mentors on the NIH-supported Infectious Diseases Training Grant.
Genetic approaches, cellular and molecular biology of intracellular pathogen infection
Structure and Assembly of the Herpes Simplex Virus Capsid.
Herpes simplex virus infection of neurons
Cellular and molecular mechanisms of Neisserial pathogenesis
Host/pathogen Interaction - Chlamydia Infection
Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Influenza, Dengue and Ebola.
Innate immunity, chronic disease, host-parasite interactions
Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
Human Herpes virus associated with malignancy, including Kaposi's Sarcoma
Mechanisms used by Bacterial Pathogens to Integrate Host- and Bacterial-derived Signals to Sense their Environment, Coordinate Gene Expression, and Cause Disease
Human Immunodeficiency; Virus Gene Expression