Pathogenesis and Infectious Disease

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Chlamydia trachomatis, the obligate intracellular bacteria responsible for sexually transmitted infections, resides and replicates in a membrane bound compartment named the inclusion. A property of the Chlamydia inclusion is its ability to undergo homotypic fusion. Snapshots of this process are shown in the above image where inclusions harboring GFP or mCherry expressing Chlamydia sequentially fuse with one another. Scale bar 10um. Courtesy Isabelle Derré.

The Microbial Pathogenesis group in the Department of Microbiology, Immunology, and Cancer Biology studies the molecular mechanisms of initiation and progression of infection by viral and bacterial pathogens.
Investigators in the Myles H. Thaler Center focus on the viral pathogens HIV, HTLV-1 and KSHV. Other viruses of departmental focus include herpes simplex virus, influenza, dengue, and Ebola.
The bacteriology group focus on intestinal infections caused by enterohemorrhagic Escherichia coli O157:H7, Salmonella typhimurium, Listeria monocytogenes and Shigella flexneri, as well as sexually transmitted infections caused by Neisseria gonorrhoeae and Chlamydia trachomatis.
Additional research in the department focuses on parasitic infections caused by Toxoplasma gondii.
The Microbial Pathogenesis faculty are affiliated with the Biomedical Sciences Graduate Program in the research disciplines of Microbiology, and Infectious Diseases and Biodefense and are mentors on the NIH-supported Infectious Diseases Training Grant.

Herve Agaisse

Agaisse, Hervé

Genetic approaches, cellular and molecular biology of intracellular pathogen infection

Jay Brown

Brown, Jay C.

Structure and Assembly of the Herpes Simplex Virus Capsid.

Anna Cliffe

Cliffe, Anna

Herpes simplex virus infection of neurons

Alison Criss

Criss, Alison K.

Cellular and molecular mechanisms of Neisserial pathogenesis

Isabelle Derre

Derré, Isabelle

Host/pathogen Interaction - Chlamydia Infection

Daniel Engel

Engel, Daniel A.

Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Influenza, Dengue and Ebola.

Sarah Ewald

Ewald, Sarah

Innate immunity, chronic disease, host-parasite interactions

Marie-Louise Hammarskjöld

Hammarskjöld, Marie-Louise

Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses

Dean Kedes

Kedes, Dean H.

Human Herpes virus associated with malignancy, including Kaposi's Sarcoma

Melissa Kendall

Kendall, Melissa M.

Mechanisms used by Bacterial Pathogens to Integrate Host- and Bacterial-derived Signals to Sense their Environment, Coordinate Gene Expression, and Cause Disease

David Rekosh

Rekosh, David M.

Human Immunodeficiency; Virus Gene Expression