Immunology

Targeting of ovarian epithelium to induce ovarian cancer. This allows analysis of the immune environment during various stages of tumor progression. Courtesy Melanie Rutkowski, PhD

Immunology is one of the most exciting and active areas in modern biology and it intersects with a wide array of other disciplines, including virology, bacteriology, and cancer biology. The scientific focus of the faculty members working in immunology range from basic lymphocyte development and regulation of the immune system to clinical trials, including: molecular aspects of B and T lymphocyte development, leukemia and lymphoma, innate immunity, regulation of immune response quality, lymphocyte trafficking, modulation of immunity to viruses and bacteria, how apoptotic cells are cleared from the body and the relevance of clearing dead cells to inflammation, tumor immunology and immunotherapy, allergic diseases, autoimmunity, neuroimmunology and immunological perturbations in cardiovascular disease.

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Examples of projects currently being pursued by our investigators include: (a) Studies by Dr. Tim Bender will determine how the transcription factor c-Myb controls a broad array of developmental and functional programming in B and T lymphocytes, with relevance to hematopoietic malignancies; (b) Dr. Loren Erickson addresses the cellular and molecular mechanisms of B lymphocyte function, and genetic susceptibility to systemic lupus erythematosus and multiple myeloma; (c) Dr. Vic Engelhard identifies novel peptides on tumor cells and tests how specific antigenic peptides derived from the tumors can be used in immunotherapies; and (d) Studies by Dr. Ulrike Lorenz examine how immune tolerance is maintained through the balance of T cell activation and suppression and how intracellular signaling pathways regulate the functional interactions between effector and regulatory T cells.

The research in immunology uses cutting edge methodologies to probe a wide array of exciting questions. Dr. Kodi Ravichandran uses genetically engineered mice that delete or inducibly express a gene of interest (with a fluorescence tag) in a tissue specific and temporal manner to determine how phagocytes clear dying cells from a tissue. Dr. Young Hahn uses a complex set of in vitro and in vivo tools to track the Hepatitis C virus to determine how the virus evades the immune system. Dr. Melanie Rutkowski examines the interplay between our microbiome and tumorigenesis and the Sarah Ewald laboratory leverages novel optical micro-proteomics tools to study inflammation in human tissue and disease.  Research programs in immunology are supported by a state-of-the-art flow cytometry facility, transgenic/knockout mouse core facility, high through put DNA sequencing and bioinformatics cores, and a two-photon microscopy facility to assist the research of faculty members, graduate students and post-doctoral fellows.

It is important to recognize that faculty who work in the area of immunology collaborate extensively with those who study microbial pathogenesis since how pathogens are recognized and cleared by the immune system are integral to understanding microbial disease and the resolution of the immune response. Similarly, several of the immunology faculty study tumors and how they are controlled by the immune system as well as devising new immune system based tumor therapies. Such interactions between the different arms of the MIC Department greatly broaden the scope of research being pursued as well as enrich the intellectual rigor and depth in addressing the key scientific problems.

Timothy Bender

Bender, Timothy P.

Regulation of gene expression during lymphocyte development

Amy Bouton

Bouton, Amy H.

Signaling Pathways and Breast Cancer

Alison Criss

Criss, Alison K.

Cellular and molecular mechanisms of Neisserial pathogenesis

Victor Engelhard

Engelhard, Victor H.

Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Role of lymphatic endothelial cells in regulating immunity and self-tolerance

Loren Erickson

Erickson, Loren D.

Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus; Immunotherapeutics in the treatment of B cell disorders

Sarah Ewald

Ewald, Sarah

Innate immunity, chronic disease, host-parasite interactions

Young Hahn

Hahn, Young S.

Immune regulation for HCV infection and chronic liver inflammation

Marie-Louise Hammarskjöld

Hammarskjöld, Marie-Louise

Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses

Dean Kedes

Kedes, Dean H.

Human Herpes virus associated with malignancy, including Kaposi's Sarcoma

Ulrike Lorenz

Lorenz, Ulrike M.

Involvement of the protein tyrosine phosphatase SHP-1 in signal transduction pathways

Kodi Ravichandran

Ravichandran, Kodi S.

Apoptotic cell clearance mechanisms in health and disease

David Rekosh

Rekosh, David M.

Human Immunodeficiency; Virus Gene Expression

Melanie Rutkowski

Rutkowski, Melanie

Influence of commensal microbes on immune homeostasis, anti-tumor immunity, and metastasis