Cancer Biology

Kashatus Lab

A human epithelial cell undergoing division. A rapidly dividing cancer cell must coordinate the equal distribution of several diverse cellular components to each of its daughter cells. Proper segregation of the mitochondrial network requires the small GTPase RalA and its effector RalBP1. In this cell, mitochondria are stained with MitoTracker dye (red), actin is stained with phalloidin (green) and DNA is stained with DAPI (blue). Courtesy of the Kashatus Lab.

Understanding human cancers and developing strategies for treating specific cancers has been at the forefront of biology for many decades. The nature of investigations into this area continues to evolve as we understand more and face newer challenges. The Cancer Biology faculty within MIC focus on cutting-edge basic cancer research as well as exposure to state-of-the-art clinical cancer patient care and treatment. Areas of research include signaling in cancer cells, mechanisms of genetic and cellular perturbations that predispose to cancer, influence of the tumor microenvironment on tumor progression and metastases, and tumor immunology and immunotherapy.

Examples of projects currently undertaken by our faculty include:

    • Dr. Amy Bouton studying how altered signaling in tumor cells and the tumor microenvironment can influence tumor progression;
    • Studies of Dr. David Kashatus on how the dynamics of mitochondrial fission and fusion contribute to tumor initiation and growth; and
    • Studies of Dr. Roger Abounader on how c-Met and PTEN regulate brain tumors.

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Investigations in Cancer Biology by our faculty use cutting-edge methodologies to probe many different questions related to tumor initiation, progression and therapies. Our investigators use a variety of genetically engineered tumor mouse models and sophisticated 3D culture models, along with state-of-the-art microscopy, including two-photon, electron, and super-resolution microscopy. For example, Dr. Kwon Park is using a combination of genetically engineered mice and 3D cell culture systems to identify and characterize genetic drivers of small cell lung cancer; Dr. Drew Dudley’s lab is focused on vascular biology and cancer and is studying how vascular dysfunction in tumors contributes to tumor progression and metastasis; Dr. Hui Zong is using a genetic mosaic mouse model to study tumor cell dynamics in vivo at single-cell resolution; Dr. David Brautigan is using novel approaches in enzymology, genomics, and genetics to study how phosphatases control cell cycle and tumor cell proliferation. Since cancer therapeutics is a major focus of the UVA School of Medicine, there is substantial interaction between faculty members addressing basic questions in cancer biology and clinicians in the UVA Health System (examples include those of Drs. Jill Slack-Davis and Susan Modesitt addressing ovarian cancers as part of the Women’s Oncology group, Drs. Engelhard and Craig Slingluff addressing tumor immunotherapy/peptide vaccines for melanomas). In addition to providing an exciting way to both ask and address fundamentally important questions in cancer biology, such interactions provide an intellectually stimulating training environment for students and post-doctoral fellows. It is important to recognize that many of the faculty whose research focuses on cancer biology collaborate extensively with those working in immunology and infectious disease. Such interactions broaden the scope of the questions that can be asked and enrich the intellectual rigor and depth that can be achieved in addressing the key scientific problems.


Roger Abounader

Abounader, Roger

Basic and translational brain tumor research

Timothy Bender

Bender, Timothy P.

Regulation of gene expression during lymphocyte development

Amy Bouton

Bouton, Amy H.

Signaling Pathways and Breast Cancer

David Brautigan

Brautigan, David L.

Protein Phosphorylation in Cell Signaling

Jay Brown

Brown, Jay C.

Structure and Assembly of the Herpes Simplex Virus Capsid.

Andrew Dudley

Dudley, Andrew

Tumor microenvironment and mechanisms of tumor neovascularization

Victor Engelhard

Engelhard, Victor H.

Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Role of lymphatic endothelial cells in regulating immunity and self-tolerance

Loren Erickson

Erickson, Loren D.

Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus; Immunotherapeutics in the treatment of B cell disorders

Sarah Ewald

Ewald, Sarah

Innate immunity, chronic disease, host-parasite interactions

Daniel Gioeli

Gioeli, Daniel

Signal transduction in cancer cells

Marie-Louise Hammarskjöld

Hammarskjöld, Marie-Louise

Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses

David Kashatus

Kashatus, David F

The Role of Mitochondrial Fusion and Fission in Tumorigenesis.

Dean Kedes

Kedes, Dean H.

Human Herpes virus associated with malignancy, including Kaposi's Sarcoma

Ulrike Lorenz

Lorenz, Ulrike M.

Involvement of the protein tyrosine phosphatase SHP-1 in signal transduction pathways

Kwon-Sik Park

Park, Kwon-Sik

Mechanisms of tumor progression and homeostasis

Lucy Pemberton

Pemberton, Lucy F.

Nuclear Transport in Chromatin Assembly and Transcriptional Regulation

Kodi Ravichandran

Ravichandran, Kodi S.

Apoptotic cell clearance mechanisms in health and disease

David Rekosh

Rekosh, David M.

Human Immunodeficiency; Virus Gene Expression

Melanie Rutkowski

Rutkowski, Melanie

Influence of commensal microbes on immune homeostasis, anti-tumor immunity, and metastasis

Michael Weber

Weber, Michael J.

Targeting Cell Signaling for Cancer Therapy.

Hui Zong

Zong, Hui

Mouse models of brain cancers