Cell signaling is the process where cells respond to their environment – hormones, growth factors, drugs, metabolites, etc. – and continuously make a decision to live, grow and proliferate, or die. It’s that dramatic. Signaling research here at UVA has discovered enzymes such as protein kinases that integrate inputs from the environment to determine cell fate. These enzymes are the molecular receptors of new generations of pharmaceuticals called “targeted therapies”. Current research in MIC uses genetic and pharmacological tools to discover and understand the operation of signaling networks, especially in cancer. We use cell lines in culture, as well as preclinical xenograft and genetic animal models to study what factors drive cancer, and how cancers respond to and evade therapy. Results of this research translate into improved treatment for patients of today and tomorrow.
Basic and translational brain tumor research
Regulation of gene expression during lymphocyte development
Signaling Pathways and Breast Cancer
Protein Phosphorylation in Cell Signaling
Cellular and molecular mechanisms of Neisserial pathogenesis
Tumor microenvironment and mechanisms of tumor neovascularization
Drug Discovery and Molecular Biology of Pathogenic RNA viruses: Influenza, Dengue and Ebola.
Identification of MHC-restricted tumor antigens / Control of T cell homing to tumors / Role of lymphatic endothelial cells in regulating immunity and self-tolerance
Cellular and molecular mechanisms of B lymphocyte function; Genetic susceptibility in systemic lupus erythematosus; Immunotherapeutics in the treatment of B cell disorders
Signal transduction in cancer cells
Post Transcriptional Gene Regulation and the Molecular Biology of Human Retroviruses
The Role of Mitochondrial Fusion and Fission in Tumorigenesis.
Involvement of the protein tyrosine phosphatase SHP-1 in signal transduction pathways
Mechanisms of tumor progression and homeostasis
Nuclear Transport in Chromatin Assembly and Transcriptional Regulation
Apoptotic cell clearance mechanisms in health and disease
Influence of commensal microbes on immune homeostasis, anti-tumor immunity, and metastasis
Targeting Cell Signaling for Cancer Therapy.
Mouse models of brain cancers