Publications
Recent Publications:
2021
Drake JC, Wilson RJ, Laker RC, Guan Y, Spaulding HR, Shen W, Shang H, Dorn MV, Huang K, Zhang M, Bandara AB, Kashatus JA, Sharma PR, Young A, Gautam J, Cao R, Wallrabe H, Chang PA, Wong M, Hawley SA, Christ GJ, Kashatus DF, Miller CL, Wolf MJ, Periasamy A, Steinberg GR, Hardie DG, Yan Z, Mitochondria-localized AMPK mediates exercise and energetic stress-induced mitophagy, PNAS, 118(37): e2025932118, (2021)
Hussain SS, Tran T-M, Ware TB, Luse MA, Prevost CT, Ferguson AN, Kashatus JA, Hsu K-L, Kashatus DF, RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal, Cell Rep., 36(4): 109451, (2021)
2020
Rohani A, Kashatus JA, Sessions DT, Sharmin S, and Kashatus DF, MitoHacker: A Set of Tools to Enable High-Throughput Analysis of Mitochondrial Network Morphology, Sci. Rep., 10(1): 18941, (2020)
Chauhan SS, Toth RK, Jensen CC, Casillas A, Kashatus DF, and Warfel NA, PIM kinase inhibitors promote mitochondrial fission and combat chemoresistance in non-small cell lung cancer, Oncogene, 39(12): 2597-2611, (2020)
Przanowska RK, Sobierajska E, Su Z, Jensen K, Przanowski P, Nagdas S, Kashatus JA, Kashatus DF, Bhatnagar S, Lukens JR, and Dutta A, miR-206 family is important for mitochondrial and muscle function, but not essential for myogenesis, FASEB J., 34(6): 7687-7702, (2020)
2019
Nagdas S, Kashatus JA, Nascimento A, Hussain SS, Trainor RE, Pollock SR, Adair SJ, Michaels AD, Sesaki H, Stelow EB, Bauer TW and Kashatus DF, Drp1 promotes KRas-driven metabolic changes and pancreatic tumor growth. Cell Reports, 28(7): 1845-1859.e5, (2019)
Pollock SR, Schinlever AR, Rohani A, Kashatus JA and Kashatus DF, RalA and RalB relocalization to depolarized mitochondria depends on clathrin-mediated endocytosis and facilitates TBK1 activation. PLOS One, 14(4): e0214764, (2019).
2018
Wilson RJ, Drake JC, Cui D, Lewellyn B, Fisher C, Zhang M, Kashatus DF, Palmer LA, Murphy MP and Yan Z, Mitochondrial protein S-nitrosylation protects against ischemia-reperfusion-induced denervation at the neuromuscular junction in skeletal muscle. Free. Radic. Biol. Med., 117: 180-190 (2018).
Wallrabea H, Svindrych Z, Alam SR, Siller KH, Wang T, Kashatus D, Hu S, and Periasamy A, Segmented cell analyses to measure redox states of autofluorescent NAD(P)H, FAD & Trp in cancer cells by FLIM, Sci. Rep., 8(1): 79 (2018).
Pollock, SR. and Kashatus, DF. Ral. In: Choi, Sangdun, Editor, Encyclopedia of Signaling Molecules, 2nd Edition, Springer Press, (2018).
Kashatus DF, Mitochondrial dynamics regulation of tumor cell physiology Biochem. Biophys. Res. Commun., 500(1): 9-16. (2018).
2017
Wilson RJ, Drake JC, Cui D, Zhang M, Perry HM, Kashatus JA, Kusminski C, Scherer P, Kashatus DF, Okusa MD and Yan Z, Conditional MitoTimer reporter mice for assessment of mitochondrial structure, oxidative stress, and mitophagy. Mitochondrion, DOI:10.1016/j.mito.2017.12.008 (2017).
Perry HM, Huang L, Wilson RJ, Bajwa A, Sesaki H, Yan Z, Rosin DL, Kashatus DF, Okusa MD, Dynamin Related Protein 1 Deficiency Promotes Recovery from Acute Kidney Injury. J. Am. Soc. Nephrol., 29(1): 194-206 (2017).
Rohani A, Moore JA, Kashatus JA, Sesaki H, Kashatus DF and Swami N, Label-free quantification of intracellular mitochondrial dynamics using dielectrophoresis. Anal. Chem., 89(11): 5757-5764 (2017).
Nagdas S and Kashatus DF, The interplay between oncogenic signaling networks and mitochondrial dynamics. Antioxidants, 6(2): 33 (2017).
Nascimento A, Lannigan J, and Kashatus DF, Detection and quantification of mitochondrial fusion through imaging flow cytometry. Curr. Protoc. Cytom., 81: 9.53.1–9.53.13 (2017).
2016
Kashatus DF, Restraining the Divider: A Drp1-Phospholipid Interaction Inhibits Drp1 Activity and Shifts the Balance from Mitochondrial Fission to Fusion. Mol. Cell., 63(6): 913-5 (2016).
Nascimento A, Lannigan J, and Kashatus DF, High-Throughput detection and quantification of mitochondrial fusion through Imaging Flow Cytometry, Cytometry, 89: 708–719 (2016).
Kashatus DF, The many roles of Ral GTPases in Ras-driven cancer, In: Azmi, A, editor. Conquering Ras: From Biology to Therapy; Elsevier Academic Press; (2016).
2015
Xie Q, Wu Q, Horbinski C, Flavahan WA, Yang K, Zhou W, Dombrowski S, Huang Z, Fang X, Ferguson AN, Kashatus DF, Bao S, and Rich JN, Mitochondrial Control by DRP1 in Brain Tumor Initiating Cells, Nat. Neurosci., 18(4): 501-510 (2015).
Kashatus JA*, Nascimento A*, Myers LJ, Sher A, Byrne FL, Hoehn KL, Counter CM, and Kashatus DF, Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth, Mol. Cell, 57: 537–551 (2015). (*co-first authors).
2014
Kashatus DF, An in vitro system to evaluate the scaffold function of the RalA effector protein RalBP1, In: Trabalzini, L & Retta, S, editors. Methods in Molecular Biology: vol. 1120, Ras Signaling; Humana Press (2014).
2013
Kashatus DF, Ral GTPases in tumorigenesis: emerging from the shadows, Exp. Cell Res., 319(15): 2337-42 (2013).
Pubmed Listings for David Kashatus, Ph.D.