Mitochondrial Dynamics and Cancer

We have identified a link between mutations in Ras, which are found in one third of human tumors, and mitochondrial fission. We are currently exploring how tumors use changes in mitochondrial shape to reprogram their metabolism and fuel rapid proliferation.

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Lipid Droplets and Nutrient Deprivation

Cells in the body regularly encounter differences in the availability of key nutrients and respond with a variety of metabolic changes. We have identified a new pathway regulating the growth of lipid droplets during nutrient deprivation and are currently working to explore how these unique organelles contribute to both normal and pathological physiology.

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Analysis of Mitochondrial Dynamics and Cellular Physiology

We are developing new tools to analyze mitochondrial structure and function across a wide variety of cells and tissues in order to identify novel relationships between mitochondria and the physiological changes associated with cancer and other metabolic diseases.

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