Kashatus Lab

The Kashatus Lab, within the Department of Microbiology, Immunology and Cancer Biolog (MIC), is interested in the regulation of mitochondrial dynamics and how alterations in mitochondrial fission and fusion affect basic cellular physiology. We explore these questions using a wide variety of approaches, from cell biology to mouse genetics to bioinformatics with the ultimate goal of identifying how mitochondrial dynamics and metabolic function impact the progression of cancer and other diseases. 

Mitochondrial Dynamics and Cancer

We have identified a link between mutations in Ras, which are found in one third of human tumors, and mitochondrial fission. We are currently exploring how tumors use changes in mitochondrial shape to reprogram their metabolism and fuel rapid proliferation.

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research image depicting lipid droplets

Lipid Droplets and Nutrient Deprivation

Cells in the body regularly encounter differences in the availability of key nutrients and respond with a variety of metabolic changes. We have identified a new pathway regulating the growth of lipid droplets during nutrient deprivation and are currently working to explore how these unique organelles contribute to both normal and pathological physiology.

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Analysis of Mitochondrial Dynamics and Cellular Physiology

We are developing new tools to analyze mitochondrial structure and function across a wide variety of cells and tissues in order to identify novel relationships between mitochondria and the physiological changes associated with cancer and other metabolic diseases.

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Twitter Feed

Mariano A. Garcia-Blanco, MD, PhD, will lead our Department of Microbiology, Immunology and Cancer Biology. He is an internationally recognized expert in virology and RNA biology and comes to UVA from the University of Texas Medical Branch. @DeanMKibbe http://ow.ly/T4GE50KLGTI

📢 We are very excited to share our new paper on Oma1 and #ferroptosis in #mitochondrial #cardiomyopathy

@sahola6 et al. unraveled the role of Oma1-Dele1-Atf4 mediated ISR in the protection from lipid peroxidation and ferroptosis in vivo

http://shorturl.at/bGMU4

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We are hiring! Looking for postdoc candidates with experience in murine tumor models, mitochondria and metabolism for a collaborative project with @papinsysbio, Bauer Lab and Wotton Lab! Email if interested! Apply at link below. Please RT! @SascoVirginia https://uva.wd1.myworkdayjobs.com/UVAJobs/job/Charlottesville-VA/Postdoctoral-Research-Associate--Kashatus-Lab_R0040330

We are excited to announce the Systems Analysis of Stress-adapted Cancer Organelles (SASCO) U54 Center of the NCI-sponsored Cancer Systems Biology Consortium!
@janeslab @LazzaraLab @kashatuslab @papinsysbio @MFallahiSichani @Kristen_naegle @hui_zong @shaynalefrak @Kristen_atkins https://twitter.com/UVAEngineers/status/1570019765720080384

UVA Engineering @UVAEngineers

.@UVA’s $12M NIH-funded cancer research center to leverage UVA's expertise in cancer systems biology and biomedical data science: https://2ogp.short.gy/5nShAk @UVABME @SascoVirginia @uvachechair @MedicineUVA @uvahealthnews

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