2021 MIC Student Publications

Salmonella Typhimurium manipulates macrophage cholesterol homeostasis through the SseJ-mediated suppression of the host cholesterol transport protein ABCA1. Greene AR, Owen KA, Casanova JE. Cell Microbiol. 2021 Aug;23(8):e13329. doi: 10.1111/cmi.13329. Epub 2021 Apr 22. PMID: 33742761

Differential Expression of CD49a and CD49b Determines Localization and Function of Tumor-Infiltrating CD8+ T Cells.
Melssen MM, Lindsay RS, Stasiak K, Rodriguez AB, Briegel AM, Cyranowski S, Rutkowski MR, Conaway MR, Melief CJM, van der Burg SH, Eyo U, Slingluff CL Jr, Engelhard VH. Cancer Immunol Res. 2021 May;9(5):583-597. doi: 10.1158/2326-6066.CIR-20-0427. Epub 2021 Feb 22. PMID: 33619119; PMCID: PMC8102369.

Detergent wash improves vaccinated lymph node handling ex vivo.
Ball AG, Belanger MC, Pompano RR. J Immunol Methods. 2021 Feb;489:112943. doi: 10.1016/j.jim.2020.112943. Epub 2020 Dec 14. PMID: 33333059; PMCID: PMC7855487.

Characteristics of Immune Memory and Effector Activity to Cancer-Expressed MHC Class I Phosphopeptides Differ in Healthy Donors and Ovarian Cancer Patients.
Lulu AM, Cummings KL, Jeffery ED, Myers PT, Underwood D, Lacy RM, Chianese- Bullock KA, Slingluff CL Jr, Modesitt SC, Engelhard VH. Cancer Immunol Res. 2021 Aug 19. doi: 10.1158/2326-6066.CIR-21-0111. Epub ahead of print. PMID: 34413086.

IL-13 is a driver of COVID-19 severity.
Donlan AN, Sutherland TE, Marie C, Preissner S, Bradley BT, Carpenter RM, Sturek JM, Ma JZ, Moreau GB, Donowitz JR, Buck GA, Serrano MG, Burgess SL, Abhyankar MM, Mura C, Bourne PE, Preissner R, Young MK, Lyons GR, Loomba JJ, Ratcliffe SJ, Poulter MD, Mathers AJ, Day AJ, Mann BJ, Allen JE, Petri WA Jr. JCI Insight. 2021 Aug 9;6(15):e150107. doi: 10.1172/jci.insight.150107. PMID: 34185704; PMCID: PMC8410056.

Neuroimmune cleanup crews in brain injury.
Bolte AC, Lukens JR. Trends Immunol. 2021 Jun;42(6):480-494. doi: 10.1016/j.it.2021.04.003. Epub 2021 Apr 30. PMID: 33941486; PMCID: PMC8165004.

Mitochondrial dynamics in cancer stem cells.
Sessions DT, Kashatus DF. Cell Mol Life Sci. 2021 Apr;78(8):3803-3816. doi: 10.1007/s00018-021-03773-2. Epub 2021 Feb 13. PMID: 33580834.

De Novo Polycomb Recruitment: Lessons from Latent Herpesviruses.
Dochnal SA, Francois AK, Cliffe AR. Viruses. 2021 Jul 27;13(8):1470. doi: 10.3390/v13081470. PMID: 34452335; PMCID: PMC8402699.

Microbes exploit death-induced nutrient release by gut epithelial cells.
Anderson CJ, Medina CB, Barron BJ, Karvelyte L, Aaes TL, Lambertz I, Perry JSA, Mehrotra P, Gonçalves A, Lemeire K, Blancke G, Andries V, Ghazavi F, Martens A, van Loo G, Vereecke L, Vandenabeele P, Ravichandran KS. Nature. 2021 Aug;596(7871):262-267. doi: 10.1038/s41586-021-03785-9. Epub 2021 Aug 4. PMID: 34349263.

Licensing Natural Killers for Antiviral Immunity.
Cronk JM, Fafoutis E, Brown MG. Pathogens. 2021 Jul 19;10(7):908. doi: 10.3390/pathogens10070908. PMID: 34358058; PMCID: PMC8308748.

Putting the brakes on phagocytosis: “don’t-eat-me” signaling in physiology and disease.
Kelley SM, Ravichandran KS. EMBO Rep. 2021 Jun 4;22(6):e52564. doi: 10.15252/embr.202152564. Epub 2021 May 27. PMID: 34041845; PMCID: PMC8183410.

HLA class I and II associations with common enteric pathogens in the first year of life.
McCowin SE, Moreau GB, Haque R, Noble JA, McDevitt SL, Donowitz JR, Alam MM, Kirkpatrick BD, Petri WA, Marie C.  EBioMedicine. 2021 May;67:103346. doi: 10.1016/j.ebiom.2021.103346. Epub 2021 Apr 25. PMID: 33910121; PMCID: PMC8093888.

Lewis Blood-group Antigens Are Associated With Altered Susceptibility to Shigellosis.
Leslie JL, Weddle E, Yum LK, Lin Y, Jenior ML, Lee B, Ma JZ, Kirkpatrick BD, Nayak U, Platts-Mills JA, Agaisse HF, Haque R, Petri WA. Clin Infect Dis. 2021 Jun 1;72(11):e868-e871. doi: 10.1093/cid/ciaa1409. PMID: 32940644; PMCID: PMC8315233.

Immune mechanisms orchestrate tertiary lymphoid structures in tumors via cancer-associated fibroblasts.
Rodriguez AB, Peske JD, Woods AN, Leick KM, Mauldin IS, Meneveau MO, Young SJ, Lindsay RS, Melssen MM, Cyranowski S, Parriott G, Conaway MR, Fu YX, Slingluff CL Jr, Engelhard VH.  Cell Rep. 2021 Jul 20;36(3):109422. doi: 10.1016/j.celrep.2021.109422. PMID: 34289373; PMCID: PMC8362934.

Acute Lymph Node Slices Are a Functional Model System to Study Immunity Ex Vivo.
Belanger MC, Ball AG, Catterton MA, Kinman AWL, Anbaei P, Groff BD, Melchor SJ, Lukens JR, Ross AE, Pompano RR.  ACS Pharmacol Transl Sci. 2021 Jan 8;4(1):128-142. doi: 10.1021/acsptsci.0c00143. PMID: 33615167; PMCID: PMC7887751.

RalA and PLD1 promote lipid droplet growth in response to nutrient withdrawal.
Hussain SS, Tran TM, Ware TB, Luse MA, Prevost CT, Ferguson AN, Kashatus JA, Hsu KL, Kashatus DF. Cell Rep. 2021 Jul 27;36(4):109451. doi: 10.1016/j.celrep.2021.109451. PMID: 34320341; PMCID: PMC8344381.

Parasite protein pirates host cytoskeletal modulator during invasion.
McCowin S, Marie C, Petri WA Jr.  Trends Parasitol. 2021 Nov;37(11):937-939. doi: 10.1016/j.pt.2021.09.004. Epub 2021 Sep 28. PMID: 34598896.

A pathogen-specific sRNA influences enterohemorrhagic Escherichia coli fitness and virulence in part by direct interaction with the transcript encoding the ethanolamine utilization regulatory factor EutR.
Sauder AB, Kendall MM.  Nucleic Acids Res. 2021 Sep 30:gkab863. doi: 10.1093/nar/gkab863. Epub ahead of print. PMID: 34591974.

PML-NB-dependent type I interferon memory results in a restricted form of HSV latency.
Suzich JB, Cuddy SR, Baidas H, Dochnal S, Ke E, Schinlever AR, Babnis A, Boutell C, Cliffe AR.  EMBO Rep. 2021 Sep 6;22(9):e52547. doi: 10.15252/embr.202152547. Epub 2021 Jul 1. PMID: 34197022; PMCID: PMC8419685.

Rapid Fabrication by Digital Light Processing 3D Printing of a SlipChip with Movable Ports for Local Delivery to Ex Vivo Organ Cultures.
Catterton MA, Ball AG, Pompano RR.  Micromachines (Basel). 2021 Aug 20;12(8):993. doi: 10.3390/mi12080993. PMID: 34442615; PMCID: PMC8399530.

Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation.
Medina CB, Chiu YH, Stremska ME, Lucas CD, Poon I, Tung KS, Elliott MR, Desai B, Lorenz UM, Bayliss DA, Ravichandran KS. Immunity. 2021 Aug 10;54(8):1715-1727.e7. doi: 10.1016/j.immuni.2021.06.014. Epub 2021 Jul 21. PMID: 34283971; PMCID: PMC8363584.