2020 MIC Student Publications

Metabolites released from apoptotic cells act as tissue messengers.
Medina CB, Mehrotra P, Arandjelovic S, Perry JSA, Guo Y, Morioka S, Barron B, Walk SF, Ghesquière B, Krupnick AS, Lorenz U, Ravichandran KS.  Nature. 2020 Apr;580(7801):130-135. doi: 10.1038/s41586-020-2121-3. Epub 2020 Mar 18. PMID: 32238926; PMCID: PMC7217709.

Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis.
Bolte AC, Dutta AB, Hurt ME, Smirnov I, Kovacs MA, McKee CA, Ennerfelt HE, Shapiro D, Nguyen BH, Frost EL, Lammert CR, Kipnis J, Lukens JR.  Nat Commun. 2020 Sep 10;11(1):4524. doi: 10.1038/s41467-020-18113-4. PMID: 32913280; PMCID: PMC7483525.

Insights into Tumor-Associated Tertiary Lymphoid Structures: Novel Targets for Antitumor Immunity and Cancer Immunotherapy.
Rodriguez AB, Engelhard VH. Cancer Immunol Res. 2020 Nov;8(11):1338-1345. doi: 10.1158/2326-6066.CIR-20-0432. PMID: 33139300; PMCID: PMC7643396.

Evaluation of K18-hACE2 Mice as a Model of SARS-CoV-2 Infection.
Moreau GB, Burgess SL, Sturek JM, Donlan AN, Petri WA, Mann BJ. Am J Trop Med Hyg. 2020 Sep;103(3):1215-1219. doi: 10.4269/ajtmh.20-0762. PMID: 32723427; PMCID: PMC7470527.

Effect of Lipidation on the Localization and Activity of a Lysozyme Inhibitor in Neisseria gonorrhoeae.
Ragland SA, Gray MC, Melson EM, Kendall MM, Criss AK. J Bacteriol. 2020 Mar 26;202(8):e00633-19. doi: 10.1128/JB.00633-19. PMID: 32041800; PMCID: PMC7099142.

Mito Hacker: a set of tools to enable high-throughput analysis of mitochondrial network morphology.
Rohani A, Kashatus JA, Sessions DT, Sharmin S, Kashatus DF. Sci Rep. 2020 Nov 3;10(1):18941. doi: 10.1038/s41598-020-75899-5. PMID: 33144635; PMCID: PMC7642274.

Retroviral Overexpression of CXCR4 on Murine B-1a Cells and Adoptive Transfer for Targeted B-1a Cell Migration to the Bone Marrow and IgM Production.
Upadhye A, Marshall M, Garmey JC, Bender TP, McNamara C. J Vis Exp. 2020 May 31;(159):10.3791/61003. doi: 10.3791/61003. PMID: 32538902; PMCID: PMC7863627.

Targeting the ion channel TRPM7 promotes the thymic development of regulatory T cells by promoting IL-2 signaling.
Mendu SK, Stremska ME, Schappe MS, Moser EK, Krupa JK, Rogers JS, Stipes EJ, Parker CA, Braciale TJ, Perry JSA, Desai BN. Sci Signal. 2020 Dec 8;13(661):eabb0619. doi: 10.1126/scisignal.abb0619. PMID: 33293462; PMCID: PMC7884026.

Neuronal hyperexcitability is a DLK-dependent trigger of herpes simplex virus reactivation that can be induced by IL-1.
Cuddy SR, Schinlever AR, Dochnal S, Seegren PV, Suzich J, Kundu P, Downs TK, Farah M, Desai BN, Boutell C, Cliffe AR. Elife. 2020 Dec 22;9:e58037. doi: 10.7554/eLife.58037. PMID: 33350386; PMCID: PMC7773336.

Imaging Flow Cytometry Analysis of CEACAM Binding to Opa-Expressing Neisseria
gonorrhoeae.
Werner LM, Palmer A, Smirnov A, Belcher Dufrisne M, Columbus L, Criss AK. Cytometry A. 2020 Jun 2. doi: 10.1002/cyto.a.24037. Epub ahead of print. PMID: 32484607.

Murine Endometrial Organoids to Model Chlamydia Infection.
Bishop RC, Boretto M, Rutkowski MR, Vankelecom H, Derré I. Front Cell Infect Microbiol. 2020 Aug 14;10:416. doi: 10.3389/fcimb.2020.00416. PMID: 32923409; PMCID: PMC7456808.

Host and Bacterial Glycolysis During Chlamydia trachomatis Infection.
Ende RJ, Derré I. Infect Immun. 2020 Sep 8:IAI.00545-20. doi: 10.1128/IAI.00545-20. Epub ahead of print. PMID: 32900818.

Models and molecular mechanisms of blood vessel co-option by cancer cells.
Zhang Y, Wang S, Dudley AC. Angiogenesis. 2020;23(1):17-25. doi:10.1007/s10456-019-09684 PMID: 31628560 PMCID: PMC7018564

The molecular biology and immune control of chronic Toxoplasma gondii infection.
Zhao XY, Ewald SE. J Clin Invest. 2020 Jul 1;130(7):3370-3380. doi:10.1172/JCI136226. PMID: 32609097; PMCID: PMC7324197.

The Ethanolamine-Sensing Transcription Factor EutR Promotes Virulence and Transmission during Citrobacter rodentium Intestinal Infection. Infect Immun.
Rowley CA, Sauder AB, Kendall MM. 2020 Aug 19;88(9):e00137-20. doi:10.1128/IAI.00137-20. PMID: 32631916; PMCID: PMC7440760.

RIPK3-dependent recruitment of low-inflammatory myeloid cells does not protect from systemic Salmonella infection.
Satkovich J, Anderson CJ, Medina Chris, Ottolini Matteo, Lukens J, Kendall MM*. mBio. 2020.

Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth.
Yao M, Ventura PB, Jiang Y, Rodriguez FJ, Wang L, Perry JSA, Yang Y, Wahl K, Crittenden RB, Bennett ML, Qi L, Gong CC, Li XN, Barres BA, Bender TP, Ravichandran KS, Janes KA, Eberhart CG, Zong H. Cell. 2020 Feb 6;180(3):502-520.e19. doi:10.1016/j.cell.2019.12.024. Epub 2020 Jan 23. PMID: 31983537; PMCID: PMC7259679.

Mosaic Analysis with Double Markers reveals IGF1R function in granule cell progenitors during cerebellar development.
Terry TT, Cheng T, Mahjoub M, Zong H. Dev Biol. 2020 Sep 15;465(2):130-143. doi: 10.1016/j.ydbio.2020.07.008. Epub 2020 Jul 19. PubMed PMID: 32697974; NIHMSID:NIHMS1616035.

Whole Genome Sequencing of Spontaneously Occurring Rat Natural Killer Large Granular Lymphocyte Leukemia Identifies JAK1 Somatic Activating Mutation.
Wang TT, Yang J, Dighe S, Schmachtenberg MW, Leigh NT, Farber E, Onengut-Gumuscu S, Feith DJ, Ratan A, Loughran TP Jr, Olson TL. Cancers (Basel).2020 Jan 3;12(1):126. doi: 10.3390/cancers12010126. PMID: 31947841; PMCID: PMC7017127.

Evaluation of K18-hACE2 Mice as a Model of SARS-CoV-2 Infection.
Moreau GB, Burgess SL, Sturek JM, Donlan AN, Petri WA, Mann BJ. Am J Trop Med Hyg. 2020 Sep;103(3):1215-1219. doi: 10.4269/ajtmh.20-0762. PMID: 32723427; PMCID: PMC7470527.

Dual Function of Aar, a Member of the New AraC Negative Regulator Family, in Escherichia coli Gene Expression.
Mickey AS, Nataro JP. Infect Immun. 2020 May 20;88(6):e00100-20. doi: 10.1128/IAI.00100-20. PMID: 32253248; PMCID: PMC7240098.

Type 2 Cytokines IL-4 and IL-5 Reduce Severe Outcomes from Clostridiodes difficile Infection.
Donlan A, Simpson ME, Petri WA Jr., M.D., Ph.D. Anaerobe 2020, in press.

IL-13 Predicts the Need for Mechanical Ventilation in COVID-19 Patients.
Donlan AD, Young M, Petri WA Jr., Abhyankar M. medRxiv 2020.06.18.20134353; doi:https://doi.org/10.1101/2020.06.18.20134353

Ten simple rules for reading a scientific paper.
Carey MA, Steiner KL, Petri WA Jr. PLoS Comput Biol. 2020 Jul 30;16(7):e1008032. doi: 10.1371/journal.pcbi.1008032. PMID: 32730251; PMCID: PMC7392212.

Considering the Immune System during Fecal Microbiota Transplantation for Clostridioides difficile Infection.
Frisbee AL, Petri WA Jr. Trends Mol Med. 2020 May;26(5):496-507. doi: 10.1016/j.molmed.2020.01.009. Epub 2020 Feb 17. PMID: 32359480; PMCID: PMC7198612.

Mucosal immunity and the eradication of polio.
Donlan AN, Petri WA Jr. Science. 2020 Apr 24;368(6489):362-363. doi: 10.1126/science.abb8588. PMID: 32327582.

The Inflammasome and Type-2 Immunity in Clostridium difficile Infection.
Donlan A, Petri WA Jr. Clin Colon Rectal Surg. 2020 Mar;33(2):67-72. doi: 10.1055/s-0040-1701231. Epub 2020 Feb 25. PMID: 32104158; PMCID: PMC7042014.

Inhibition of Amebic Cysteine Proteases Blocks Amebic Trogocytosis but Not Phagocytosis.
Gilmartin AA, Ralston KS, Petri WA. J Infect Dis. 2020 Apr 27;221(10):1734-1739. doi: 10.1093/infdis/jiz671. PMID: 31999350; PMCID: PMC7184912.

Gasdermin-D-dependent IL-1α release from microglia promotes protective immunity during chronic Toxoplasma gondii infection.
Batista SJ, Still KM, Johanson D, Thompson JA, OʼBrien CA, Lukens JR, Harris TH. Nat Commun. 2020 Jul 23;11(1):3687. doi: 10.1038/s41467-020-17491-z. PMID: 32703941; PMCID: PMC7378823.

Long-‘Trm’ protection of the CNS.
Kovacs MA, Harris TH. Nat Immunol. 2020 Aug;21(8):825-826. doi: 10.1038/s41590-020-0716-3. PMID: 32572243.

ICOS-deficient and ICOS YF mutant mice fail to control Toxoplasma gondii infection of the brain.
O’Brien CA, Harris TH. PLoS One. 2020 Jan 24;15(1):e0228251. doi: 10.1371/journal.pone.0228251. PMID: 31978191; PMCID: PMC6980566.

Human TH1 and TH2 cells targeting rhinovirus and allergen coordinately promote allergic asthma.
Muehling LM, Heymann PW, Wright PW, Eccles JD, Agrawal R, Carper HT, Murphy DD, Workman LJ, Word CR, Ratcliffe SJ, Capaldo BJ, Platts-Mills TAE, Turner RB, Kwok WW, Woodfolk JA. J Allergy Clin Immunol. 2020 Sep;146(3):555-570. doi: 10.1016/j.jaci.2020.03.037. PMID: 32320734; PMCID: PMC7483727.

T-bet+ Memory B Cells Link to Local Cross-Reactive IgG upon Human Rhinovirus Infection.
Eccles JD, Turner RB, Kirk NA, Muehling LM, Borish L, Steinke JW, Payne SC, Wright PW, Thacker D, Lahtinen SJ, Lehtinen MJ, Heymann PW, Woodfolk JA. Cell Rep. 2020 Jan 14;30(2):351-366.e7. PMID: 31940481; PMCID: PMC6994188.