2015 Publications MIC Faculty and Students

Synergistic apoptosis in head and neck squamous cell carcinoma cells by co-inhibition of insulin-like growth factor-1 receptor signaling and compensatory signaling pathways.
Axelrod MJ, Mendez RE, Khalil A, Leimgruber SS, Sharlow ER, Capaldo B, Conaway M, Gioeli DG, Weber MJ, Jameson MJ.
Head Neck. 2015 Dec;37(12):1722-32. doi: 10.1002/hed.23822. Epub 2015 Apr 6.
PMID: 24986420
Integrative analysis to select cancer candidate biomarkers to targeted validation.
Kawahara R, Meirelles GV, Heberle H, Domingues RR, Granato DC, Yokoo S, Canevarolo RR, Winck FV, Ribeiro AC, Brandão TB, Filgueiras PR, Cruz KS, Barbuto JA, Poppi RJ, Minghim R, Telles GP, Fonseca FP, Fox JW, Santos-Silva AR, Coletta RD, Sherman NE, Paes Leme AF.
Oncotarget. 2015 Dec 22;6(41):43635-52. doi: 10.18632/oncotarget.6018. PMID:26540631
Preventing the Androgen Receptor N/C Interaction Delays Disease Onset in a Mouse Model of SBMA.
Zboray L, Pluciennik A, Curtis D, Liu Y, Berman-Booty LD, Orr C, Kesler CT, Berger T, Gioeli D, Paschal BM, Merry DE.
Cell Rep. 2015 Dec 15;13(10):2312-23. doi: 10.1016/j.celrep.2015.11.019. Epub 2015 Dec 7. PMID: 26673324
Xanthophylls lutein and zeaxanthin modify gene expression and induce synthesis of hyaluronan in keratinocyte model of human skin.
Li, R, Turner, S.D. and Brautigan, D. L.
Biochemistry & Biophysics Reports 4: 52-58.(2015)
Small but Mighty: Selected Commensal Bacterial Species Determine the Effectiveness of Anti-cancer Immunotherapies.
Conejo-Garcia JR, Rutkowski MR.
Immunity. 2015 Dec 15;43(6):1037-9. doi: 10.1016/j.immuni.2015.11.014. PMID: 26682980
Checkpoint Kinase 2 Negatively Regulates Androgen Sensitivity and Prostate Cancer Cell Growth.
Ta HQ, Ivey ML, Frierson HF Jr, Conaway MR, Dziegielewski J, Larner JM, Gioeli D.
Cancer Res. 2015 Dec 1;75(23):5093-105. doi: 10.1158/0008-5472.CAN-15-0224. Epub 2015 Nov 16. PMID: 26573794
Ethanolamine Signaling Promotes Salmonella Niche Recognition and Adaptation during Infection.
Anderson CJ, Clark DE, Adli M, Kendall MM.
PLoS Pathog. 2015 Nov 13;11(11):e1005278. doi: 10.1371/journal.ppat.1005278. eCollection 2015 Nov. Erratum in:PLoS Pathog. 2015 Dec;11(12):e1005365. PMID: 26565973
HIV-1 Group O Origin, Evolution, Pathogenesis, and Treatment: Unraveling the Complexity of an Outlier 25 Years Later.
Bush S, Tebit DM.
AIDS Rev. 2015 Jul-Sep;17(3):147-58.
PMID: 26450803
Defining the fitness of HIV-1 isolates with dual/mixed co-receptor usage.
Nankya IL, Tebit DM, Abraha A, Kyeyune F, Gibson R, Jegede O, Nickel G, Arts EJ.
AIDS Res Ther. 2015 Oct 3;12:34. doi: 10.1186/s12981-015-0066-7. eCollection 2015.
PMID: 26435727
Phagocytosis of apoptotic cells in homeostasis.
Arandjelovic S, Ravichandran KS.
Nat Immunol. 2015 Sep;16(9):907-17. doi: 10.1038/ni.3253. Review. PMID: 26287597
Pannexin 1 channels regulate leukocyte emigration through the venous endothelium during acute inflammation.
Lohman AW, Leskov IL, Butcher JT, Johnstone SR, Stokes TA, Begandt D, DeLalio LJ, Best AK, Penuela S, Leitinger N, Ravichandran KS, Stokes KY, Isakson BE.
Nat Commun. 2015 Aug 5;6:7965. doi: 10.1038/ncomms8965. PMID: 26242575
Women at extreme risk for obesity-related carcinogenesis: Baseline endometrial pathology and impact of bariatric surgery on weight, metabolic profiles and quality of life.
Modesitt SC, Hallowell PT, Slack-Davis JK, Michalek RD, Atkins KA, Kelley SL, Arapovic S, Shupnik MA, Hoehn K.
Gynecol Oncol. 2015 Aug;138(2):238-45. doi: 10.1016/j.ygyno.2015.05.015. Epub 2015 May 23. PMID: 26013696
Hepcidin and Host Defense against Infectious Diseases.
Michels K, Nemeth E, Ganz T, Mehrad B.
PLoS Pathog. 2015 Aug 20;11(8):e1004998. doi: 10.1371/journal.ppat.1004998. eCollection 2015 Aug. Review. PMID:26291319
An improved method for differentiating cell-bound from internalized particles by imaging flow cytometry.
Smirnov A, Solga MD, Lannigan J, Criss AK
J Immunol Methods. 2015 Aug;423:60-9. doi: 10.1016/j.jim.2015.04.028. Epub 2015 May 9. PMID: 25967947
The Bug Stops Here: Innate Lymphoid Cells in Clostridium difficile Infection.
Buonomo EL, Petri WA Jr.
Cell Host Microbe. 2015 Jul 8;18(1):5-6. doi: 10.1016/j.chom.2015.06.015. PMID:26159713
Analysis of cytokine production by peanut-reactive T cells identifies residual Th2 effectors in highly allergic children who received peanut oral immunotherapy.
Wisniewski JA, Commins SP, Agrawal R, Hulse KE, Yu MD, Cronin J, Heymann PW, Pomes A, Platts-Mills TA, Workman L, Woodfolk JA.
Clin Exp Allergy. 2015 Jul;45(7):1201-13. doi: 10.1111/cea.12537. PMID: 25823600
Editorial: NK cell reaping of Tfh cells: reckless slaughter or sensible pruning?
Brown MG, Erickson LD.
J Leukoc Biol. 2015 Aug;98(2):139-42. doi: 10.1189/jlb.4CE0415-175R. Epub 2015 Jun 5. No abstract available. PMID: 26048981
Exploring the role of environmental enteropathy in malnutrition, infant development and oral vaccine response.
Gilmartin AA, Petri WA Jr. Philos Trans R Soc Lond B
Biol Sci. 2015 Jun 19;370(1671). pii: 20140143. doi: 10.1098/rstb.2014.0143. Review. PMID:25964455
MEK2 is a prognostic marker and potential chemo-sensitizing target for glioma patients undergoing temozolomide treatment.
He H, Yao M, Zhang W, Tao B, Liu F, Li S, Dong Y, Zhang C, Meng Y, Li Y, Hu G, Luo C, Zong H, Lu Y.
Cell Mol Immunol. 2015 Jul 20. doi: 10.1038/cmi.2015.46. [Epub ahead of print] PMID: 26189368
B-1b Cells Secrete Atheroprotective IgM and Attenuate Atherosclerosis.
Rosenfeld SM, Perry HM, Gonen A, Prohaska TA, Srikakulapu P, Grewal S, Das D, McSkimming C, Taylor AM, Tsimikas S, Bender TP, Witztum JL, McNamara CA.
Circ Res. 2015 Jul 17;117(3):e28-39. doi: 10.1161/CIRCRESAHA.117.306044. Epub 2015 Jun 16. PMID: 26082558
A thermonuclease of Neisseria gonorrhoeae enhances bacterial escape from killing by neutrophil extracellular traps.
Juneau RA, Stevens JS, Apicella MA, Criss AK.
J Infect Dis. 2015 Jul 15;212(2):316-24. doi: 10.1093/infdis/jiv031. Epub 2015 Jan 20. PMID: 25605868
Chlamydiae interaction with the endoplasmic reticulum: contact, function and consequences.
Derré I.
Cell Microbiol. 2015 Jul;17(7):959-66. doi: 10.1111/cmi.12455. Epub 2015 May 27. Review. PMID: 25930206
A novel mechanism of generating extracellular vesicles during apoptosis via a beads-on-a-string membrane structure.
Atkin-Smith GK, Tixeira R, Paone S, Mathivanan S, Collins C, Liem M, Goodall KJ, Ravichandran KS, Hulett MD, Poon IK.
Nat Commun. 2015 Jun 15;6:7439. doi: 10.1038/ncomms8439. PMID: 26074490
Site-specific albumination of a therapeutic protein with multi-subunit to prolong activity in vivo.
Lim SI, Hahn YS, Kwon I.
J Control Release. 2015 Jun 10;207:93-100. doi: 10.1016/j.jconrel.2015.04.004. Epub 2015 Apr 7. PMID: 25862515
The lipooligosaccharide-modifying enzyme LptA enhances gonococcal defence against human neutrophils.
Handing JW, Criss AK.
Cell Microbiol. 2015 Jun;17(6):910-21. doi: 10.1111/cmi.12411. Epub 2015 Feb 4. PMID: 25537831
Opa+ Neisseria gonorrhoeae exhibits reduced survival in human neutrophils via Src family kinase-mediated bacterial trafficking into mature phagolysosomes. Johnson MB, Ball LM, Daily KP, Martin JN, Columbus L, Criss AK.
Cell Microbiol. 2015 May;17(5):648-65. doi: 10.1111/cmi.12389. Epub 2014 Nov 25. PMID:25346239
The HIV-1 Rev response element (RRE) adopts alternative conformations that promote different rates of virus replication.
Sherpa C, Rausch JW, Le Grice SF, Hammarskjold ML, Rekosh D.
Nucleic Acids Res. 2015 May 19;43(9):4676-86. doi: 10.1093/nar/gkv313. Epub 2015 Apr 8. PMID: 25855816
Effector lymphocyte-induced lymph node-like vasculature enables naive T-cell entry into tumours and enhanced anti-tumour immunity.
Peske JD, Thompson ED, Gemta L, Baylis RA, Fu YX, Engelhard VH.
Nat Commun. 2015 May 13;6:7114. doi: 10.1038/ncomms8114. PMID:  25968334
Cadherin-6B is required for the generation of Islet-1-expressing dorsal interneurons. Park KS,
Gumbiner BM.
Biochem Biophys Res Commun. 2015 Apr 10;459(3):504-8. doi: 10.1016/j.bbrc.2015.02.136. Epub 2015 Mar 5. PMID: 25747715
Liver-resident CD103+ dendritic cells prime antiviral CD8+ T cells in situ.
Krueger PD, Kim TS, Sung SS, Braciale TJ, Hahn YS.
J Immunol. 2015 Apr 1;194(7):3213-22. doi: 10.4049/jimmunol.1402622. Epub 2015 Feb 23. PMID:25712214
The “Performance of Rotavirus and Oral Polio Vaccines in Developing Countries” (PROVIDE) study: description of methods of an interventional study designed to explore complex biologic problems.
Kirkpatrick BD, Colgate ER, Mychaleckyj JC, Haque R, Dickson DM, Carmolli MP, Nayak U, Taniuchi M, Naylor C, Qadri F, Ma JZ, Alam M, Walsh MC, Diehl SA; PROVIDE Study Teams, Petri WAJr.
Am J Trop Med Hyg. 2015 Apr;92(4):744-51. doi: 10.4269/ajtmh.14-0518. Epub 2015 Feb 23. PMID: 25711607
Roles of lymphatic endothelial cells expressing peripheral tissue antigens in CD4 T-cell tolerance induction.
Rouhani SJ, Eccles JD, Riccardi P, Peske JD, Tewalt EF, Cohen JN, Liblau R, Mäkinen T, Engelhard VH.
Nat Commun. 2015 Apr 10;6:6771. doi: 10.1038/ncomms7771. PMID: 25857745
Cell-cycle-dependent regulation of androgen receptor function.
Koryakina Y, Knudsen KE, Gioeli D.
Endocr Relat Cancer. 2015 Apr;22(2):249-64. doi: 10.1530/ERC-14-0549. Epub 2015 Feb 17. PMID: 25691442
Liver-resident CD103+ dendritic cells prime antiviral CD8+ T cells in situ.
Krueger PD, Kim TS, Sung SS, Braciale TJ, Hahn YS.
J Immunol. 2015 Apr 1;194(7):3213-22. doi: 10.4049/jimmunol.1402622. Epub 2015 Feb 23. PMID: 25712214
ShcA regulates thymocyte proliferation through specific transcription factors and a c-Abl-dependent signaling axis.
Trampont PC, Zhang L, Giles AJ, Walk SF, Gu JJ, Pendergast AM, Ravichandran KS.
Mol Cell Biol. 2015 Apr;35(8):1462-76. doi: 10.1128/MCB.01084-14. Epub 2015 Feb 17. PMID: 25691660
Mitochondrial control by DRP1 in brain tumor initiating cells.
Xie Q, Wu Q, Horbinski CM, Flavahan WA, Yang K, Zhou W, Dombrowski SM, Huang Z, Fang X, Shi Y, Ferguson AN, Kashatus DF, Bao S, Rich JN.
Nat Neurosci. 2015 Apr;18(4):501-10. doi: 10.1038/nn.3960. Epub 2015 Mar 2. PMID: 25730670
Tissue localization and extracellular matrix degradation by PI, PII and PIII snake venom metalloproteinases: clues on the mechanisms of venom-induced hemorrhage.
Herrera C, Escalante T, Voisin MB, Rucavado A, Morazán D, Macêdo JK, Calvete JJ, Sanz L, Nourshargh S, Gutiérrez JM, Fox JW.
PLoS Negl Trop Dis. 2015 Apr 24;9(4):e0003731. doi: 10.1371/journal.pntd.0003731. eCollection 2015 Apr. PMID: 25909592
RNA and lessons from viruses.
Hammarskjöld ML.
RNA. 2015 Apr;21(4):632-3. doi: 10.1261/rna.050310.115. No abstract available. PMID: 25780169
Evolutionary conservation of a molecular machinery for export and expression of mRNAs with retained introns.
Wang B, Rekosh D, Hammarskjold ML.
RNA. 2015 Mar;21(3):426-37. doi: 10.1261/rna.048520.114. Epub 2015 Jan 20. PMID: 25605961
A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells.
Billaud M, Chiu YH, Lohman AW, Parpaite T, Butcher JT, Mutchler SM, DeLalio LJ, Artamonov MV, Sandilos JK, Best AK, Somlyo AV, Thompson RJ, Le TH, Ravichandran KS, Bayliss DA, Isakson BE.
Sci Signal. 2015 Feb 17;8(364):ra17. doi: 10.1126/scisignal.2005824. PMID: 25690012
ShcA regulates late stages of T cell development and peripheral CD4+ T cell numbers.
Buckley MW, Trampont PC, Arandjelovic S, Fond AM, Juncadella IJ, Ravichandran KS.
J Immunol. 2015 Feb 15;194(4):1665-76. doi: 10.4049/jimmunol.1401728. Epub 2015 Jan 16. PMID: 25595778
Chemical biology. A small-molecule inhibitor of the aberrant transcription factor CBFβ-SMMHC delays leukemia in mice.
Illendula A, Pulikkan JA, Zong H, Grembecka J, Xue L, Sen S, Zhou Y, Boulton A, Kuntimaddi A, Gao Y, Rajewski RA, Guzman ML, Castilla LH, Bushweller JH.
Science. 2015 Feb 13;347(6223):779-84. doi: 10.1126/science.aaa0314. PMID: 25678665
Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth.
Kashatus JA, Nascimento A, Myers LJ, Sher A, Byrne FL, Hoehn KL, Counter CM, Kashatus DF.
Mol Cell. 2015 Feb 5;57(3):537-51. doi: 10.1016/j.molcel.2015.01.002. PMID: 25658205
Cell of origin for malignant gliomas and its implication in therapeutic development.
Zong H, Parada LF, Baker SJ.
Cold Spring Harb Perspect Biol. 2015 Jan 29;7(5). pii: a020610. doi: 10.1101/cshperspect.a020610. Review. PMID: 25635044
Cooperation between Noncanonical Ras Network Mutations.
Stites EC, Trampont PC, Haney LB, Walk SF, Ravichandran KS.
Cell Rep. 2015 Jan 15. pii: S2211-1247(14)01064-X. doi: 10.1016/j.celrep.2014.12.035. [Epub ahead of print] PMID: 25600866
Histone variants and epigenetics.
Henikoff S, Smith MM.
Cold Spring Harb Perspect Biol. 2015 Jan 5;7(1):a019364. doi: 10.1101/cshperspect.a019364. Review. PMID: 25561719
Control of CD8 T-Cell Infiltration into Tumors by Vasculature and Microenvironment.
Peske JD, Woods AB, Engelhard VH.
Adv Cancer Res. 2015;128:263-307. doi: 10.1016/bs.acr.2015.05.001. Epub 2015 Jun 1. Review. PMID: 26216636
Disintegrins from snake venoms and their applications in cancer research and therapy.
Arruda Macêdo JK, Fox JW, de Souza Castro M.
Curr Protein Pept Sci. 2015;16(6):532-48. Review. PMID: 26031306
Using phosphatidylserine exposure on apoptotic cells to stimulate myoblast fusion.
Hochreiter-Hufford AE, Arandjelovic S, Ravichandran KSMethods Mol Biol. 2015;1313:141-8. doi: 10.1007/978-1-4939-2703-6_10. PMID: 25947662
Systems Analysis of Adaptive Responses to MAP Kinase Pathway Blockade in BRAF Mutant Melanoma.
Capaldo BJ, Roller D, Axelrod MJ, Koeppel AF, Petricoin EF, Slingluff CL Jr, Weber MJ, Mackey AJ,Gioeli D, Bekiranov S.
PLoS One. 2015 Sep 25;10(9):e0138210. doi: 10.1371/journal.pone.0138210. eCollection 2015. PMID: 26405815
Combined PDGFR and HDAC Inhibition Overcomes PTEN Disruption in Chordoma.
Lee DH, Zhang Y, Kassam AB, Park MJ, Gardner P, Prevedello D, Henry S, Horbinski C, Beumer JH, Tawbi H, Williams BJ, Shaffrey ME, Egorin MJ, Abounader R, Park DM.
PLoS One. 2015 Aug 6;10(8):e0134426. doi: 10.1371/journal.pone.0134426. eCollection 2015. PMID: 26247786
Optical Imaging of Paramagnetic Bead-DNA Aggregation Inhibition Allows for Low Copy Number Detection of Infectious Pathogens.
DuVall JA, Borba JC, Shafagati N, Luzader D, Shukla N, Li J, Kehn-Hall K, Kendall MM, Feldman SH, Landers JP.
PLoS One. 2015 Jun 11;10(6):e0129830. doi: 10.1371/journal.pone.0129830. eCollection 2015. PMID: 26068926
Decreased peritoneal ovarian cancer growth in mice lacking expression of lipid phosphate phosphohydrolase 1.
Nakayama J, Raines TA, Lynch KR, Slack-Davis JK.
PLoS One. 2015 Mar 13;10(3):e0120071. doi: 10.1371/journal.pone.0120071. eCollection 2015. PMID: 25769037
BAFF regulates follicular helper t cells and affects their accumulation and interferon-γ production in autoimmunity.
Coquery CM, Loo WM, Wade NS, Bederman AG, Tung KS, Lewis JE, Hess H, Erickson LD.
Arthritis Rheumatol. 2015 Mar;67(3):773-84. doi: 10.1002/art.38950. PMID: 25385309
Legionella pneumophila utilizes a single-player disulfide-bond oxidoreductase system to manage disulfide bond formation and isomerization.
Kpadeh ZZ, Day SR, Mills BW, Hoffman PS.
Mol Microbiol. 2015 Mar;95(6):1054-69. doi: 10.1111/mmi.12914. Epub 2015 Jan 30. PMID: 25534767
Ebola virus and severe acute respiratory syndrome coronavirus display late cell entry kinetics: evidence that transport to NPC1+ endolysosomes is a rate-defining step.
Mingo RM, Simmons JA, Shoemaker CJ, Nelson EA, Schornberg KL, D’Souza RS, Casanova JE, White JM.
J Virol. 2015 Mar;89(5):2931-43. doi: 10.1128/JVI.03398-14. Epub 2014 Dec 31. PMID: 25552710
Inflammasome activation contributes to interleukin-23 production in response to Clostridium difficile.
Cowardin CA, Kuehne SA, Buonomo EL, Marie CS, Minton NP, Petri WA Jr.
MBio. 2015 Jan 27;6(1). pii: e02386-14. doi: 10.1128/mBio.02386-14. PMID:25626905
VCAM-1 on peritoneum and α4β1 integrin in endometrium and their implications in endometriosis.
Schutt AK, Atkins KA, Slack-Davis JK, Stovall DW.
Int J Gynecol Pathol. 2015 Jan;34(1):85-9. doi: 10.1097/PGP.0000000000000118.
PMID: 25473757