2019 Publication MIC Faculty and Students

Models and molecular mechanisms of blood vessel co-option by cancer cells.
Zhang Y, Wang S, Dudley AC. Angiogenesis. 2019 Oct 18. doi: 10.1007/s10456-019-09684-y. [Epub ahead of print] Review. PMID: 31628560

Genomics of LGL leukemia and select other rare leukemia/lymphomas.
Moosic KB, Paila U, Olson KC, Dziewulska K, Wang TT, Xing JC, Ratan A, Feith DJ, Loughran TP Jr, Olson TL.
Best Pract Res Clin Haematol. 2019 Sep;32(3):196-206. doi: 10.1016/j.beha.2019.06.003. Epub 2019 Jun 6. Review.
PMID; 31585620

Phosphatidylserine on viable sperm and phagocytic machinery in oocytes regulate mammalian fertilization.
Rival CM, Xu W, Shankman LS, Morioka S, Arandjelovic S, Lee CS, Wheeler KM, Smith RP, Haney LB, Isakson BE, Purcell S, Lysiak JJ, Ravichandran KS.
Nat Commun. 2019 Oct 1;10(1):4456. doi: 10.1038/s41467-019-12406-z. PMID: 31575859

Type 3 immunity during Clostridioides difficile infection: too much of a good thing?
Saleh MM, Petri WA Jr.
nfect Immun. 2019 Sep 30. pii: IAI.00306-19. doi: 10.1128/IAI.00306-19. [Epub ahead of print] Review.
PMID: 31570564

Mechanisms of bacillary dysentery: lessons learnt from infant rabbits.
Yum LK, Agaisse H.
Gut Microbes. 2019 Oct 1:1-6. doi: 10.1080/19490976.2019.1667726. [Epub ahead of print]
PMID: 31570038

Diversification and CXCR4-Dependent Establishment of the Bone Marrow B-1a Cell Pool Governs Atheroprotective IgM Production Linked to Human Coronary Atherosclerosis.
Upadhye A, Srikakulapu P, Gonen A, Hendrikx S, Perry HM, Nguyen A, McSkimming C, Marshall MA, Garmey JC, Taylor AM, Bender TP, Tsimikas S, Holodick NE, Rothstein TL, Witztum JL, McNamara CA.
Circ Res. 2019 Oct 25;125(10):e55-e70. doi: 10.1161/CIRCRESAHA.119.315786. Epub 2019 Sep 24.
PMID; 31549940

Ciliogenesis associated kinase 1: targets and functions in various organ systems.
Fu Z, Gailey CD, Wang EJ, Brautigan DL.
FEBS Lett. 2019 Sep 10. doi: 10.1002/1873-3468.13600. [Epub ahead of print] Review.
PMID: 31506943

MicroRNA-29a inhibits glioblastoma stem cells and tumor growth by regulating the PDGF pathway.
Yang Y, Dodbele S, Park T, Glass R, Bhat K, Sulman EP, Zhang Y, Abounader R.
2019 Oct;145(1):23-34. doi: 10.1007/s11060-019-03275-z. Epub 2019 Sep 3.
PMID: 31482267

Evolutionary Perspectives on the Moonlighting Functions of Bacterial Factors That Support Actin-Based Motility.
Köseoğlu VK, Agaisse H.
MBio. 2019 Aug 27;10(4). pii: e01520-19. doi: 10.1128/mBio.01520-19.
PMID: 31455648

Antitumor effect of insulin-like growth factor-1 receptor inhibition in head and neck squamous cell carcinoma.
Lehman CE, Khalil AA, Axelrod MJ, Dougherty MI, Schoeff SS, Taniguchi LE, Mendez RE, David AP, McGarey PO Jr.,, Hubbard MA, Donaldson L, Frierson HF Jr.,, Stelow EB, Bekiranov S, Wulfkuhle JD, Petricoin EF, Gioeli DG, Jameson MJ.
Laryngoscope. 2019 Aug 21. doi: 10.1002/lary.28236. [Epub ahead of print]
PMID: 31433065

The Barrier Molecules Junction Plakoglobin, Filaggrin, and Dystonin Play Roles in Melanoma Growth and Angiogenesis.
Leick KM, Rodriguez AB, Melssen MM, Benamar M, Lindsay RS, Eki R, Du KP, Parlak M, Abbas T, Engelhard VH, Slingluff CL Jr.
Ann Surg. 2019 Oct;270(4):712-722. doi: 10.1097/SLA.0000000000003522.
PMID: 31425296

WIPF2 promotes Shigella flexneri actin-based motility and cell-to-cell spread.
Michard C, Yum LK, Agaisse H.
Cell Microbiol. 2019 Aug 14:e13098. doi: 10.1111/cmi.13098. [Epub ahead of print]
PMID: 31414511

Drp1 Promotes KRas-Driven Metabolic Changes to Drive Pancreatic Tumor Growth.
Nagdas S, Kashatus JA, Nascimento A, Hussain SS, Trainor RE, Pollock SR, Adair SJ, Michaels AD, Sesaki H, Stelow EB, Bauer TW, Kashatus DF.
Cell Rep. 2019 Aug 13;28(7):1845-1859.e5. doi: 10.1016/j.celrep.2019.07.031.
PMID: 31412251

A Coinfection Model to Evaluate Chlamydia Inc Protein Interactions.
Ende R, Derré I.
Methods Mol Biol. 2019;2042:205-218. doi: 10.1007/978-1-4939-9694-0_14.
PMID: 31385278

IL-1β/TNF-α/IL-6 inflammatory cytokines promote STAT1-dependent induction of CH25H in Zika virus-infected human macrophages.
Magoro T, Dandekar A, Jennelle LT, Bajaj R, Lipkowitz G, Angelucci AR, Bessong PO, Hahn YS.
J Biol Chem. 2019 Oct 4;294(40):14591-14602. doi: 10.1074/jbc.RA119.007555. Epub 2019 Aug 2.
PMID: 31375561

Abdominal Pain and Intermittent Fevers in a 16-Year-Old Girl.
Penberthy K, Mendoza J, Mendoza M, Harrison G, Lancaster L, Belyea B, Zeichner SL.
Pediatrics. 2019 Sep;144(3). pii: e20190093. doi: 10.1542/peds.2019-0093. Epub 2019 Aug 2.
PMID: 31375532

Inhibition of Ebola Virus by a Molecularly Engineered Banana Lectin.
Covés-Datson EM, Dyall J, DeWald LE, King SR, Dube D, Legendre M, Nelson E, Drews KC, Gross R, Gerhardt DM, Torzewski L, Postnikova E, Liang JY, Ban B, Shetty J, Hensley LE, Jahrling PB, Olinger GG Jr, White JM, Markovitz DM.
PLoS Negl Trop Dis. 2019 Jul 29;13(7):e0007595. doi: 10.1371/journal.pntd.0007595. eCollection 2019 Jul.
PMID: 31356611

Cell intrinsic functions of neutrophils and their manipulation by pathogens.
Allen LH, Criss AK.
Curr Opin Immunol. 2019 Oct;60:124-129. doi: 10.1016/j.coi.2019.05.004. Epub 2019 Jul 11. Review.
PMID: 31302568

Cutaneous Exposure to Clinically Relevant Lone Star Ticks Promotes IgE Production and Hypersensitivity through CD4+ T Cell- and MyD88-Dependent Pathways in Mice.
Chandrasekhar JL, Cox KM, Loo WM, Qiao H, Tung KS, Erickson LD.
J Immunol. 2019 Aug 15;203(4):813-824. doi: 10.4049/jimmunol.1801156. Epub 2019 Jul 3.
PMID: 31270149

Discovery of a novel long noncoding RNA overlapping the LCK gene that regulates prostate cancer cell growth.
Ta HQ, Whitworth H, Yin Y, Conaway M, Frierson HF Jr, Campbell MJ, Raj GV, Gioeli D.
Mol Cancer. 2019 Jun 28;18(1):113. doi: 10.1186/s12943-019-1039-6.
PMID: 31253147

A multipeptide vaccine plus toll-like receptor agonists LPS or polyICLC in combination with incomplete Freund’s adjuvant in melanoma patients.
Melssen MM, Petroni GR, Chianese-Bullock KA, Wages NA, Grosh WW, Varhegyi N, Smolkin ME, Smith KT, Galeassi NV, Deacon DH, Gaughan EM, Slingluff CL Jr.
J Immunother Cancer. 2019 Jun 27;7(1):163. doi: 10.1186/s40425-019-0625-x.
PMID: 31248461

Disease Tolerance in Toxoplasma Infection.
Melchor SJ, Ewald SE.
Front Cell Infect Microbiol. 2019 Jun 6;9:185. doi: 10.3389/fcimb.2019.00185. eCollection 2019. Review.
PMID: 31245299

The sRNA DicF integrates oxygen sensing to enhance enterohemorrhagic Escherichia coli virulence via distinctive RNA control mechanisms.
Melson EM, Kendall MM.
Proc Natl Acad Sci U S A. 2019 Jul 9;116(28):14210-14215. doi: 10.1073/pnas.1902725116. Epub 2019 Jun 24.
PMID: 31235565

IL-33 drives group 2 innate lymphoid cell-mediated protection during Clostridium difficile infection.
Frisbee AL, Saleh MM, Young MK, Leslie JL, Simpson ME, Abhyankar MM, Cowardin CA, Ma JZ, Pramoonjago P, Turner SD, Liou AP, Buonomo EL, Petri WA Jr.
Nat Commun. 2019 Jun 20;10(1):2712. doi: 10.1038/s41467-019-10733-9.
PMID: 31221971

Impact of the microbiome on cancer progression and response to anti-cancer therapies.
Buchta Rosean C, Feng TY, Azar FN, Rutkowski MR.
Adv Cancer Res. 2019;143:255-294. doi: 10.1016/bs.acr.2019.03.005. Epub 2019 Apr 17.
PMID: 31202360

Chlamydia trachomatis and Chlamydia muridarum spectinomycin resistant vectors and a transcriptional fluorescent reporter to monitor conversion from replicative to infectious bacteria.
Cortina ME, Ende RJ, Bishop RC, Bayne C, Derré I.
PLoS One. 2019 Jun 6;14(6):e0217753. doi: 10.1371/journal.pone.0217753. eCollection 2019.
PMID: 31170215

Patterns of immune-cell infiltration in murine models of melanoma: roles of antigen and tissue site in creating inflamed tumors.
Leick KM, Pinczewski J, Mauldin IS, Young SJ, Deacon DH, Woods AN, Bosenberg MW, Engelhard VH, Slingluff CL Jr.
Cancer Immunol Immunother. 2019 Jul;68(7):1121-1132. doi: 10.1007/s00262-019-02345-5. Epub 2019 May 27.
PMID: 31134297

The Antigen Processing and Presentation Machinery in Lymphatic Endothelial Cells.
Santambrogio L, Berendam SJ, Engelhard VH.
Front Immunol. 2019 May 7;10:1033. doi: 10.3389/fimmu.2019.01033. eCollection 2019. Review.
PMID: 31134089

Protocols to Interrogate the Interactions Between Neisseria gonorrhoeae and Primary Human Neutrophils.
Ragland SA, Criss AK.
Methods Mol Biol. 2019;1997:319-345. doi: 10.1007/978-1-4939-9496-0_19.
PMID: 31119632

Living on the Edge: Efferocytosis at the Interface of Homeostasis and Pathology.
Morioka S, Maueröder C, Ravichandran KS.
Immunity. 2019 May 21;50(5):1149-1162. doi: 10.1016/j.immuni.2019.04.018. Review.
PMID: 31117011

Vaccine Strategy in Melanoma.
Kwak M, Leick KM, Melssen MM, Slingluff CL Jr.
Surg Oncol Clin N Am. 2019 Jul;28(3):337-351. doi: 10.1016/j.soc.2019.02.003. Epub 2019 Apr 15. Review.
PMID: 31079792

Preexisting Commensal Dysbiosis Is a Host-Intrinsic Regulator of Tissue Inflammation and Tumor Cell Dissemination in Hormone Receptor-Positive Breast Cancer.
Buchta Rosean C, Bostic RR, Ferey JCM, Feng TY, Azar FN, Tung KS, Dozmorov MG, Smirnova E, Bos PD, Rutkowski MR.
Cancer Res. 2019 Jul 15;79(14):3662-3675. doi: 10.1158/0008-5472.CAN-18-3464. Epub 2019 May 7.
PMID: 31064848

Comparative Transcriptomic Analysis Identifies a Range of Immunologically Related Functional Elaborations of Lymph Node Associated Lymphatic and Blood Endothelial Cells.
Berendam SJ, Koeppel AF, Godfrey NR, Rouhani SJ, Woods AN, Rodriguez AB, Peske JD, Cummings KL, Turner SD, Engelhard VH.
Front Immunol. 2019 Apr 16;10:816. doi: 10.3389/fimmu.2019.00816. eCollection 2019.
PMID: 31057546

Proteomic Analysis of Human Blister Fluids Following Envenomation by Three Snake Species in India: Differential Markers for Venom Mechanisms of Action.
Macêdo JKA, Joseph JK, Menon J, Escalante T, Rucavado A, Gutiérrez JM, Fox JW.
Toxins (Basel). 2019 Apr 30;11(5). pii: E246. doi: 10.3390/toxins11050246.
PMID: 31052189

DNA Damage Meets Neurotrophin Signaling: A Delicate Balancing AKT to Maintain Virus Latency.
Cliffe AR.
Mol Cell. 2019 May 2;74(3):411-413. doi: 10.1016/j.molcel.2019.04.015.
PMID: 31051136

A novel retroviral vector system to analyze expression from mRNA with retained introns using fluorescent proteins and flow cytometry.
Jackson PEH, Huang J, Sharma M, Rasmussen SK, Hammarskjold ML, Rekosh D.
Sci Rep. 2019 Apr 23;9(1):6467. doi: 10.1038/s41598-019-42914-3.
PMID: 31015546

Critical role of bacterial dissemination in an infant rabbit model of bacillary dysentery.
Yum LK, Byndloss MX, Feldman SH, Agaisse H.
Nat Commun. 2019 Apr 23;10(1):1826. doi: 10.1038/s41467-019-09808-4.
PMID: 31015451

Colitis-Induced Th17 Cells Increase the Risk for Severe Subsequent Clostridium difficile Infection.
Saleh MM, Frisbee AL, Leslie JL, Buonomo EL, Cowardin CA, Ma JZ, Simpson ME, Scully KW, Abhyankar MM, Petri WA Jr.
Cell Host Microbe. 2019 May 8;25(5):756-765.e5. doi: 10.1016/j.chom.2019.03.003. Epub 2019 Apr 16.
PMID: 31003940

RalA and RalB relocalization to depolarized mitochondria depends on clathrin-mediated endocytosis and facilitates TBK1 activation.
Pollock SR, Schinlever AR, Rohani A, Kashatus JA, Kashatus DF.
PLoS One. 2019 Apr 17;14(4):e0214764. doi: 10.1371/journal.pone.0214764. eCollection 2019.
PMID: 30995277

The Autotransporter IcsA Promotes Shigella flexneri Biofilm Formation in the Presence of Bile Salts.
Köseoğlu VK, Hall CP, Rodríguez-López EM, Agaisse H.
Infect Immun. 2019 Jun 20;87(7). pii: e00861-18. doi: 10.1128/IAI.00861-18. Print 2019 Jul.
PMID: 30988059

Leveraging the effects of chloroquine on resistant malaria parasites for combination therapies.
Untaroiu AM, Carey MA, Guler JL, Papin JA.
BMC Bioinformatics. 2019 Apr 15;20(1):186. doi: 10.1186/s12859-019-2756-y.
PMID: 30987583

Quaking orchestrates a post-transcriptional regulatory network of endothelial cell cycle progression critical to angiogenesis and metastasis.
Azam SH, Porrello A, Harrison EB, Leslie PL, Liu X, Waugh TA, Belanger A, Mangala LS, Lopez-Berestein G, Wilson HL, McCann JV, Kim WY, Sood AK, Liu J, Dudley AC, Pecot CV.
Oncogene. 2019 Jun;38(26):5191-5210. doi: 10.1038/s41388-019-0786-6. Epub 2019 Mar 27.
PMID: 30918328

In situ 10-cell RNA sequencing in tissue and tumor biopsy samples.
Singh S, Wang L, Schaff DL, Sutcliffe MD, Koeppel AF, Kim J, Onengut-Gumuscu S, Park KS, Zong H, Janes KA.
Sci Rep. 2019 Mar 20;9(1):4836. doi: 10.1038/s41598-019-41235-9.
PMID: 30894605

Non-redundant functions of FAK and Pyk2 in intestinal epithelial repair.
Thomas KS, Owen KA, Conger K, Llewellyn RA, Bouton AH, Casanova JE.
Sci Rep. 2019 Mar 14;9(1):4497. doi: 10.1038/s41598-019-41116-1.
PMID: 30872746

Evolution of the HIV-1 Rev Response Element during Natural Infection Reveals Nucleotide Changes That Correlate with Altered Structure and Increased Activity over Time.
Sherpa C, Jackson PEH, Gray LR, Anastos K, Le Grice SFJ, Hammarskjold ML, Rekosh D.
J Virol. 2019 May 15;93(11). pii: e02102-18. doi: 10.1128/JVI.02102-18. Print 2019 Jun 1.
PMID: 30867301

Endothelial miR-30c suppresses tumor growth via inhibition of TGF-β-induced Serpine1.
McCann JV, Xiao L, Kim DJ, Khan OF, Kowalski PS, Anderson DG, Pecot CV, Azam SH, Parker JS, Tsai YS, Wolberg AS, Turner SD, Tatsumi K, Mackman N, Dudley AC.
J Clin Invest. 2019 Mar 11;130:1654-1670. doi: 10.1172/JCI123106. eCollection 2019 Mar 11.
PMID: 30855280

A murine model of diarrhea, growth impairment and metabolic disturbances with Shigella flexneri infection and the role of zinc deficiency.
Q S Medeiros PH, Ledwaba SE, Bolick DT, Giallourou N, Yum LK, Costa DVS, Oriá RB, Barry EM, Swann JR, Lima AÂM, Agaisse H, Guerrant RL.
Gut Microbes. 2019;10(5):615-630. doi: 10.1080/19490976.2018.1564430. Epub 2019 Feb 3.
PMID: 30712505

Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells.
Gemta LF, Siska PJ, Nelson ME, Gao X, Liu X, Locasale JW, Yagita H, Slingluff CL Jr, Hoehn KL, Rathmell JC, Bullock TNJ.
Sci Immunol. 2019 Jan 25;4(31). pii: eaap9520. doi: 10.1126/sciimmunol.aap9520.
PMID: 30683669

Characterization of APOBEC3 variation in a population of HIV-1 infected individuals in northern South Africa.
Matume ND, Tebit DM, Gray LR, Turner SD, Rekosh D, Bessong PO, Hammarskjöld ML.
BMC Med Genet. 2019 Jan 19;20(1):21. doi: 10.1186/s12881-018-0740-4.
PMID: 30660178

A noncanonical role for the engulfment gene ELMO1 in neutrophils that promotes inflammatory arthritis.
Arandjelovic S, Perry JSA, Lucas CD, Penberthy KK, Kim TH, Zhou M, Rosen DA, Chuang TY, Bettina AM, Shankman LS, Cohen AH, Gaultier A, Conrads TP, Kim M, Elliott MR, Ravichandran KS.
Nat Immunol. 2019 Feb;20(2):141-151. doi: 10.1038/s41590-018-0293-x. Epub 2019 Jan 14.
PMID: 30643265

To B12 or not to B12: Five questions on the role of cobalamin in host-microbial interactions.
Rowley CA, Kendall MM.
PLoS Pathog. 2019 Jan 3;15(1):e1007479. doi: 10.1371/journal.ppat.1007479. eCollection 2019 Jan. Review. No abstract available.
PMID: 30605490

Detection of Antigen-Specific CD8+ T Cells in the Livers of HCV Core Transgenic Mice.
Cobb DA, Dandekar AP, Hahn YS.
Methods Mol Biol. 2019;1911:453-458. doi: 10.1007/978-1-4939-8976-8_31.
PMID: 30593645

Complex DNA structures trigger copy number variation across the Plasmodium falciparum genome.
Huckaby AC, Granum CS, Carey MA, Szlachta K, Al-Barghouthi B, Wang YH, Guler JL.
Nucleic Acids Res. 2019 Feb 28;47(4):1615-1627. doi: 10.1093/nar/gky1268.
PMID: 30576466

An integrated framework using high-dimensional mass cytometry and fluorescent flow cytometry identifies discrete B cell subsets in patients with red meat allergy.
Cox KM, Commins SP, Capaldo BJ, Workman LJ, Platts-Mills TAE, Amir ED, Lannigan JA, Schuyler AJ, Erickson LD.
Clin Exp Allergy. 2019 May;49(5):615-625. doi: 10.1111/cea.13322. Epub 2019 Jan 8.
PMID: 30506749

Discovery and Therapeutic Exploitation of Mechanisms of Resistance to MET Inhibitors in Glioblastoma.
Cruickshanks N, Zhang Y, Hine S, Gibert M, Yuan F, Oxford M, Grello C, Pahuski M, Dube C, Guessous F, Wang B, Deveau C, Saoud K, Gallagher I, Wulfkuhle J, Schiff D, Phan S, Petricoin E, Abounader R.
Clin Cancer Res. 2019 Jan 15;25(2):663-673. doi: 10.1158/1078-0432.CCR-18-0926. Epub 2018 Sep 10.
PMID: 30201763

Correction to: Multiple receptor tyrosine kinases converge on microRNA-134 to control KRAS, STAT5B, and glioblastoma.
Zhang Y, Kim J, Mueller AC, Dey B, Yang Y, Lee DH, Hachmann J, Finderle S, Park DM, Christensen J, Schiff D, Purow B, Dutta A, Abounader R.
Cell Death Differ. 2019 Jan;26(1):197. doi: 10.1038/s41418-018-0145-0.
PMID: 29899381