2018 Publications MIC Faculty and Students

Principles of intracellular bacterial pathogen spread from cell to cell.
Weddle E, Agaisse H.
PLoS Pathog. 2018 Dec 13;14(12):e1007380. doi: 10.1371/journal.ppat.1007380. eCollection 2018 Dec. Review. No abstract available.
PMID: 30543716

The MtrCDE Efflux Pump Contributes to Survival of Neisseria gonorrhoeae From Human Neutrophils and Their Antimicrobial Components.
Handing JW, Ragland SA, Bharathan UV, Criss AK.
Front Microbiol. 2018 Nov 20;9:2688. doi: 10.3389/fmicb.2018.02688. eCollection 2018.
PMID: 30515136

Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release.
Morioka S, Perry JSA, Raymond MH, Medina CB, Zhu Y, Zhao L, Serbulea V, Onengut-Gumuscu S, Leitinger N, Kucenas S, Rathmell JC, Makowski L, Ravichandran KS.
Nature. 2018 Nov;563(7733):714-718. doi: 10.1038/s41586-018-0735-5. Epub 2018 Nov 21.
PMID: 30464343

MDVs: Spare the SOD and Spoil the Bug.
Hussain SS, Kashatus DF.
Cell Host Microbe. 2018 Nov 14;24(5):616-618. doi: 10.1016/j.chom.2018.10.013.
PMID: 30439336

Toxoplasma gondii infection triggers chronic cachexia and sustained commensal dysbiosis in mice.
Hatter JA, Kouche YM, Melchor SJ, Ng K, Bouley DM, Boothroyd JC, Ewald SE.
PLoS One. 2018 Oct 31;13(10):e0204895. doi: 10.1371/journal.pone.0204895. eCollection 2018.
PMID: 30379866

Formation and phenotypic characterization of CD49a, CD49b and CD103 expressing CD8 T cell populations in human metastatic melanoma.
Melssen MM, Olson W, Wages NA, Capaldo BJ, Mauldin IS, Mahmutovic A, Hutchison C, Melief CJM, Bullock TN, Engelhard VH, Slingluff CL Jr.
Oncoimmunology. 2018 Aug 6;7(10):e1490855. doi: 10.1080/2162402X.2018.1490855. eCollection 2018.
PMID: 30288359

Ethanolamine Influences Human Commensal Escherichia coli Growth, Gene Expression, and Competition with Enterohemorrhagic E. coli O157:H7.
Rowley CA, Anderson CJ, Kendall MM.
MBio. 2018 Oct 2;9(5). pii: e01429-18. doi: 10.1128/mBio.01429-18.
PMID: 30279284

Development and Validation of a Prediction Model for Mortality and Adverse Outcomes Among Patients With Peripheral Eosinopenia on Admission for Clostridium difficile Infection.
Kulaylat AS, Buonomo EL, Scully KW, Hollenbeak CS, Cook H, Petri WA Jr, Stewart DB Sr.
JAMA Surg. 2018 Dec 1;153(12):1127-1133. doi: 10.1001/jamasurg.2018.3174.
PMID: 30208386

Discovery and Therapeutic Exploitation of Mechanisms of Resistance to MET Inhibitors in Glioblastoma.
Cruickshanks N, Zhang Y, Hine S, Gibert M, Yuan F, Oxford M, Grello C, Pahuski M, Dube C, Guessous F, Wang B, Deveau C, Saoud K, Gallagher I, Wulfkuhle J, Schiff D, Phan S, Petricoin E, Abounader R.
Clin Cancer Res. 2019 Jan 15;25(2):663-673. doi: 10.1158/1078-0432.CCR-18-0926. Epub 2018 Sep 10.
PMID: 30201763

The p53 Pathway in Glioblastoma.
Zhang Y, Dube C, Gibert M Jr, Cruickshanks N, Wang B, Coughlan M, Yang Y, Setiady I, Deveau C, Saoud K, Grello C, Oxford M, Yuan F, Abounader R.
Cancers (Basel). 2018 Sep 1;10(9). pii: E297. doi: 10.3390/cancers10090297. Review.
PMID: 30200436

Inferring Metabolic Mechanisms of Interaction within a Defined Gut Microbiota.
Medlock GL, Carey MA, McDuffie DG, Mundy MB, Giallourou N, Swann JR, Kolling GL, Papin JA.
Cell Syst. 2018 Sep 26;7(3):245-257.e7. doi: 10.1016/j.cels.2018.08.003. Epub 2018 Sep 5.
PMID: 30195437

Identification and Characterization of Tertiary Lymphoid Structures in Murine Melanoma.
Rodriguez AB, Peske JD, Engelhard VH.
Methods Mol Biol. 2018;1845:241-257. doi: 10.1007/978-1-4939-8709-2_14.
PMID: 30141017

Gonococcal Defenses against Antimicrobial Activities of Neutrophils.
Palmer A, Criss AK.
Trends Microbiol. 2018 Dec;26(12):1022-1034. doi: 10.1016/j.tim.2018.07.003. Epub 2018 Aug 13. Review.
PMID: 30115561

Making Contact: VAP Targeting by Intracellular Pathogens.
Stanhope R, Derré I.
Contact (Thousand Oaks). 2018 Jan-Dec;1. doi: 10.1177/2515256418775512. Epub 2018 May 17.
PMID: 30101212

Strength in diversity: Understanding the pathways to herpes simplex virus reactivation.
Suzich JB, Cliffe AR.
Virology. 2018 Sep;522:81-91. doi: 10.1016/j.virol.2018.07.011. Epub 2018 Jul 14. Review.
PMID: 30014861

Neisseria gonorrhoeae employs two protein inhibitors to evade killing by human lysozyme.
Ragland SA, Humbert MV, Christodoulides M, Criss AK.
PLoS Pathog. 2018 Jul 5;14(7):e1007080. doi: 10.1371/journal.ppat.1007080. eCollection 2018 Jul.
PMID: 29975775

After the Fact(or): Posttranscriptional Gene Regulation in Enterohemorrhagic Escherichia coli O157:H7.
Sauder AB, Kendall MM.
J Bacteriol. 2018 Sep 10;200(19). pii: e00228-18. doi: 10.1128/JB.00228-18. Print 2018 Oct 1. Review.
PMID: 29967119

Endocervical and Neutrophil Lipoxygenases Coordinate Neutrophil Transepithelial Migration to Neisseria gonorrhoeae.
Stevens JS, Gray MC, Morisseau C, Criss AK.
J Infect Dis. 2018 Oct 5;218(10):1663-1674. doi: 10.1093/infdis/jiy347.
PMID: 29905822

Epithelial and Endothelial Pannexin1 Channels Mediate AKI.
Jankowski J, Perry HM, Medina CB, Huang L, Yao J, Bajwa A, Lorenz UM, Rosin DL, Ravichandran KS, Isakson BE, Okusa MD.
J Am Soc Nephrol. 2018 Jul;29(7):1887-1899. doi: 10.1681/ASN.2017121306. Epub 2018 Jun 4.
PMID: 29866797

Deadly DAaRTS destroy cancer cells via a tumor microenvironment-mediated trigger.
McCann JV, Null JL, Dudley AC.
J Clin Invest. 2018 Jul 2;128(7):2750-2753. doi: 10.1172/JCI121527. Epub 2018 Jun 4.
PMID: 29863494

Spatial, Temporal, and Functional Assessment of LC3-Dependent Autophagy in Shigella flexneri Dissemination.
Weddle E, Agaisse H.
Infect Immun. 2018 Jul 23;86(8). pii: e00134-18. doi: 10.1128/IAI.00134-18. Print 2018 Aug.
PMID: 29844234

Response by Good et al to Letter Regarding Article, “Pannexin-1 Channels as an Unexpected New Target of the Antihypertensive Drug Spironolactone”.
Good ME, Chiu YH, Poon IKH, Jaffe IZ, Bayliss DA, Isakson BE, Ravichandran KS.
Circ Res. 2018 May 25;122(11):e88-e89. doi: 10.1161/CIRCRESAHA.118.313080. No abstract available.
PMID: 29798905

Focal adhesion kinase (FAK) deficiency in mononuclear phagocytes alters murine breast tumor progression.
Llewellyn RA, Gutknecht MF, Thomas KS, Conaway MR, Bouton AH.
Am J Cancer Res. 2018 Apr 1;8(4):675-687. eCollection 2018.
PMID: 29736312

Suppression of TGFβ-mediated conversion of endothelial cells and fibroblasts into cancer associated (myo)fibroblasts via HDAC inhibition.
Kim DJ, Dunleavey JM, Xiao L, Ollila DW, Troester MA, Otey CA, Li W, Barker TH, Dudley AC.
Br J Cancer. 2018 May;118(10):1359-1368. doi: 10.1038/s41416-018-0072-3. Epub 2018 Apr 26.
PMID: 29695769

Influential Parameters for the Analysis of Intracellular Parasite Metabolomics.
Carey MA, Covelli V, Brown A, Medlock GL, Haaren M, Cooper JG, Papin JA, Guler JL.
mSphere. 2018 Apr 18;3(2). pii: e00097-18. doi: 10.1128/mSphere.00097-18. Print 2018 Apr 25.
PMID: 2966988

Next generation sequencing reveals a high frequency of CXCR4 utilizing viruses in HIV-1 chronically infected drug experienced individuals in South Africa.
Matume ND, Tebit DM, Gray LR, Hammarskjold ML, Rekosh D, Bessong PO.
J Clin Virol. 2018 Jun;103:81-87. doi: 10.1016/j.jcv.2018.02.008. Epub 2018 Feb 15.
PMID: 29661652

c-Myb Coordinates Survival and the Expression of Genes That Are Critical for the Pre-BCR Checkpoint.
Fahl SP, Daamen AR, Crittenden RB, Bender TP.
J Immunol. 2018 May 15;200(10):3450-3463. doi: 10.4049/jimmunol.1302303. Epub 2018 Apr 13.
PMID: 29654210

Superresolution microscopy reveals structural mechanisms driving the nanoarchitecture of a viral chromatin tether.
Grant MJ, Loftus MS, Stoja AP, Kedes DH, Smith MM.
Proc Natl Acad Sci U S A. 2018 May 8;115(19):4992-4997. doi: 10.1073/pnas.1721638115. Epub 2018 Apr 2.
PMID: 29610353

Transcriptional deregulation underlying the pathogenesis of small cell lung cancer.
Kim DW, Kim KC, Kim KB, Dunn CT, Park KS.
Transl Lung Cancer Res. 2018 Feb;7(1):4-20. doi: 10.21037/tlcr.2017.10.07. Review.
PMID: 29535909

The Ethanolamine Permease EutH Promotes Vacuole Adaptation of Salmonella enterica and Listeria monocytogenes during Macrophage Infection.
Anderson CJ, Satkovich J, Köseoğlu VK, Agaisse H, Kendall MM.
Infect Immun. 2018 Apr 23;86(5). pii: e00172-18. doi: 10.1128/IAI.00172-18. Print 2018 May.
PMID: 29531136

Intron retention in viruses and cellular genes: Detention, border controls and passports.
Rekosh D, Hammarskjold ML.
Wiley Interdiscip Rev RNA. 2018 May;9(3):e1470. doi: 10.1002/wrna.1470. Epub 2018 Mar 6. Review.
PMID: 29508942

Cancer vaccine formulation dictates synergy with CTLA-4 and PD-L1 checkpoint blockade therapy.
Hailemichael Y, Woods A, Fu T, He Q, Nielsen MC, Hasan F, Roszik J, Xiao Z, Vianden C, Khong H, Singh M, Sharma M, Faak F, Moore D, Dai Z, Anthony SM, Schluns KS, Sharma P, Engelhard VH, Overwijk WW.
J Clin Invest. 2018 Apr 2;128(4):1338-1354. doi: 10.1172/JCI93303. Epub 2018 Feb 26.
PMID: 29480817

Rethinking Phagocytes: Clues from the Retina and Testes.
Penberthy KK, Lysiak JJ, Ravichandran KS.
Trends Cell Biol. 2018 Apr;28(4):317-327. doi: 10.1016/j.tcb.2018.01.004. Epub 2018 Feb 14. Review.
PMID: 29454661

A new practical and versatile mouse model of proneural glioblastoma.
Abounader R.
Neuro Oncol. 2018 Feb 19;20(3):299-301. doi: 10.1093/neuonc/nox233. No abstract available.
PMID: 29432618

Revisiting the Therapeutic Potential of Bothrops jararaca Venom: Screening for Novel Activities Using Connectivity Mapping.
Nicolau CA, Prorock A, Bao Y, Neves-Ferreira AGDC, Valente RH, Fox JW.
Toxins (Basel). 2018 Feb 6;10(2). pii: E69. doi: 10.3390/toxins10020069.
PMID: 29415440

p53 and NF 1 loss plays distinct but complementary roles in glioma initiation and progression.
Gonzalez PP, Kim J, Galvao RP, Cruickshanks N, Abounader R, Zong H.
Glia. 2018 May;66(5):999-1015. doi: 10.1002/glia.23297. Epub 2018 Feb 2.
PMID: 29392777

ERα-Mediated Nuclear Sequestration of RSK2 Is Required for ER+ Breast Cancer Tumorigenesis.
Ludwik KA, McDonald OG, Brenin DR, Lannigan DA.
Cancer Res. 2018 Apr 15;78(8):2014-2025. doi: 10.1158/0008-5472.CAN-17-2063. Epub 2018 Jan 19.
PMID: 29351904

Immune Cell Infiltration and Tertiary Lymphoid Structures as Determinants of Antitumor Immunity.
Engelhard VH, Rodriguez AB, Mauldin IS, Woods AN, Peske JD, Slingluff CL Jr.
J Immunol. 2018 Jan 15;200(2):432-442. doi: 10.4049/jimmunol.1701269. Review.
PMID: 29311385

Ten simple rules for biologists learning to program.
Carey MA, Papin JA.
PLoS Comput Biol. 2018 Jan 4;14(1):e1005871. doi: 10.1371/journal.pcbi.1005871. eCollection 2018 Jan. No abstract available.
PMID: 29300745

CD47 Blockade as an Adjuvant Immunotherapy for Resectable Pancreatic Cancer.
Michaels AD, Newhook TE, Adair SJ, Morioka S, Goudreau BJ, Nagdas S, Mullen MG, Persily JB, Bullock TNJ, Slingluff CL Jr, Ravichandran KS, Parsons JT, Bauer TW.
Clin Cancer Res. 2018 Mar 15;24(6):1415-1425. doi: 10.1158/1078-0432.CCR-17-2283. Epub 2017 Dec 29.
PMID: 29288236

Pannexin 1 Channels as an Unexpected New Target of the Anti-Hypertensive Drug Spironolactone.
Good ME, Chiu YH, Poon IKH, Medina CB, Butcher JT, Mendu SK, DeLalio LJ, Lohman AW, Leitinger N, Barrett E, Lorenz UM, Desai BN, Jaffe IZ, Bayliss DA, Isakson BE, Ravichandran KS.
Circ Res. 2018 Feb 16;122(4):606-615. doi: 10.1161/CIRCRESAHA.117.312380. Epub 2017 Dec 13.
PMID: 29237722

Zinc Acquisition Mechanisms Differ between Environmental and Virulent Francisella Species.
Moreau GB, Qin A, Mann BJ.
J Bacteriol. 2018 Jan 24;200(4). pii: e00587-17. doi: 10.1128/JB.00587-17. Print 2018 Feb 15.
PMID: 29109188

Pathogenesis of Neisseria gonorrhoeae in the female reproductive tract: neutrophilic host response, sustained infection, and clinical sequelae.
Stevens JS, Criss AK.
Curr Opin Hematol. 2018 Jan;25(1):13-21. doi: 10.1097/MOH.0000000000000394. Review.
PMID: 29016383

TH1 signatures are present in the lower airways of children with severe asthma, regardless of allergic status.
Wisniewski JA, Muehling LM, Eccles JD, Capaldo BJ, Agrawal R, Shirley DA, Patrie JT, Workman LJ, Schuyler AJ, Lawrence MG, Teague WG, Woodfolk JA.
J Allergy Clin Immunol. 2018 Jun;141(6):2048-2060.e13. doi: 10.1016/j.jaci.2017.08.020. Epub 2017 Sep 20.
PMID: 28939412

Hepatocyte-derived exosomes promote T follicular regulatory cell expansion during hepatitis C virus infection.
Cobb DA, Kim OK, Golden-Mason L, Rosen HR, Hahn YS.
Hepatology. 2018 Jan;67(1):71-85. doi: 10.1002/hep.29409. Epub 2017 Nov 15.
PMID: 28749570

The regulation of tumor cell physiology by mitochondrial dynamics.
Kashatus DF.
Biochem Biophys Res Commun. 2018 May 27;500(1):9-16. doi: 10.1016/j.bbrc.2017.06.192. Epub 2017 Jul 1. Review.
PMID: 28676396