Wilkes, David S.

David Wilkes

David S. Wilkes

Primary Appointment

Education

  • BS, Biology, Villanova University
  • MD, Temple University
  • Intern, Temple University Hospital, Philadelphia, PA
  • Resident, Temple University Hospital, Philadelphia, PA
  • Fellowship, University of Texas Sourhwestern Medical Center

Contact Information

University of Virginia
School of Medicine
Charlottesville, VA 22908
Telephone: 434-982-4050
Fax: 434-982-0874
Email: dsw4n@virginia.edu

Research Interests

Immunologically mediated lung disease

Research Description

Research studies are focused on unraveling the immune mechanisms that lead to allograft destruction. Lung transplantation is a commonly utilized modality for the treatment of end stage pulmonary diseases. However, the lung is rejected more commonly than other solid organ allografts. Repeated acute rejection episodes result in chronic rejection known as bronchiolitis obliterans, the leading cause of death in lung allograft recipients. Presentation of donor major histocompatibility complex (MHC) antigens by antigen presenting cells, such as macrophages and dendritic cells, to recipient lymphocytes is the stimulus for rejection episodes. Conversely, allograft acceptance may be induced by immunizing the recipient, orally, with donor-derived MHC proteins/peptides or MHC-like" proteins prior to transplantation. This phenomenon has been shown to prevent rejection in allografts other than the lung but has not been examined in lung allograft rejection. Although donor MHC-antigens are the stimulus and target of the rejection response we have reported recently that type V collagen [col(V)] which may be MHC-"like" is also recognized as an antigen during lung allograft rejection in humans and the local immune response to lung alloantigens in mice. Since col(V) is highly conserved and non-polymorphic then this indicates that lung allograft rejection is a disease of allo- and autoimmunity. Regulatory T cells (Tregs) have a key role in suppressing autoimmune diseases. As such

Selected Publications