Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness
Molecular genetic studies in allergic disease and asthma. Immune and cellular mechanisms of rhuIL-4R. Immune mechanisms in chronic hyperplastic eosinophilic sinusitis (CHES).
T Lymphocyte Responses To Virus Infection
NK Cells and Viral Immunity, Genetics of host resistance to viral infection, Immunogenetics, Immune regulation
Pathways to enhance T cell function in tumors.
Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
Cell Biology of bacterial pathogenesis.
The innate immune response to bacterial infection.
Human lymphocyte biology and autoimmunity
Structure and Function of Bacterial Toxins: Roles in Microbial Pathogenesis and Uses in Biomedical Research
Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
Pathogenicity of Francisella tularensis and vaccines
Regulation of lung inflammation and antimicrobial immunity
Pathogenesis of diarrheagenic Escherichia coli and Shigella.
Molecular mechanisms of pathogenesis of parasitic infection
Common Allergic Diseases
Mechanisms of Tolerance and Autoimmunity to Gonad-Specific Antigens
Virus Entry into Cells: Mechanisms and Development of Anti-Viral Therapeutics
Immunologically mediated lung disease
Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.