Understanding the Molecular Basis of Macular Degeneration in Order to Hasten the Eradication of Blindness
Innate immune mechanisms of rhinovirus (RV)-induced asthma exacerbations. Immune and cellular mechanisms of asthma. Immune mechanisms in chronic hyperplastic eosinophilic sinusitis (CHES).
T Lymphocyte Responses To Virus Infection
Natural Killer Cells, Viral Immunity, Genetic basis of host resistance to viral infection, Tumor immunity, Immune cell regulation
Pathways to enhance T cell function in tumors.
Role of Arf family GTPases in vesicular transport and cytoskeleton assembly.
Cell Biology of bacterial pathogenesis.
The innate immune response to bacterial infection.
Human lymphocyte biology and autoimmunity
Hematologic malignancies; bone marrow disorders; leukemia; large granular lymphocyte (LGL)
Pathogenicity of Francisella tularensis and vaccines
Pathogenesis of diarrheagenic Escherichia coli and Shigella.
Immune mechanisms of defense against enteric (diarrheal) infections
Common Allergic Diseases
Mechanisms of Tolerance and Autoimmunity to Gonad-Specific Antigens
Virus Entry into Cells: Mechanisms and Development of Anti-Viral Therapeutics
Immunologically mediated lung disease
Cellular and molecular mechanisms of allergic disease in humans.
Pathogenesis of infectious diseases and the development of new therapies and vaccines for infectious diseases and cancers.