Associate Professor, Microbiology, Immunology, and Cancer Biology
- BS, Biochemistry, Cornell University
- PhD, University of North Carolina
Signal transduction in cancer cells
My primary research interest has focused on understanding the mechanistic underpinnings of the cell signaling networks that contribute to cancer progression and resistance to therapy. My laboratory is currently focused on two research areas:
1) We are testing the hypothesis that progression of prostate cancer to castration-resistance is frequently driven by changes in CHK2 signaling that regulate androgen receptor (AR) activity, facilitate cell proliferation, and minimize hormone dependence. These studies will uncover new information on how kinases regulate the AR and will reveal mechanistic information critical for the rational application of existing and novel therapies for (castration-resistant prostate cancer (CRPC).
2) We are developing an in vitro tumor microenvironment system for solid tumors that utilizes multiple cell types and recapitulates tumor capillary hemodynamics and biological transport. The applicability of this system is multifaceted and includes facilitating drug discovery and development, mechanistic analysis of drug responses, and development of biomarkers of response.
In addition to the two above focus areas, my collaborative interactions are focused on the molecular mechanisms of combinations of targeted molecular agents in order to overcome inherent and acquired resistance associated with traditional therapeutic approaches.
For the more detailed descriptions please go to: Gioeli Lab Site