Dudley Lab

The Dudley Lab, associated with the Department of Microbiology, Immunology and Cancer Biology (MIC), is focused on the tumor microenvironment and mechanisms of tumor neovascularization. We use transgenic tumor models, in vivo lineage tracing strategies, and endothelial cell cultures to explore differentiation and specialization of the tumor vasculature. We are also focused on how endothelial cells, and other cell types found within the tumor microenvironment such as fibroblasts, contribute to the growth, progression, and immune surveillance of solid tumors and their metastases.

 

Tumor Blood Vessel

Tumor blood vessel abnormalities

Tumor associated blood vessels have irregular diameters, they are fragile, leaky, and blood flow is abnormal; there is now good evidence that these abnormalities contribute to tumor growth, metastasis, and responses to different therapies.
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Microscopic image of a tumors cell

Tumor blood vessel and tumor microenvironment heterogeneity

Endothelial cells in tumors display a spectrum of responses to TGF beta that underlies the plasticity and dysfunctional features of tumor-associated vasculature.
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Green dye to show the Mechanisms of tumor neovascularization

Mechanisms of tumor neovascularization

Solid tumors have diverse mechanisms for creating new blood vessels or utilizing the pre-existing vasculature to enable their survival.
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Connect with Dudley Lab

Twitter Feed

The MYC oncogene — the grand orchestrator of cancer growth and immune evasion | Nature Reviews Clinical Oncology https://www.nature.com/articles/s41571-021-00549-2

Excited to share our lab's most recent paper @NatureComms. Led by Dr. Mehwish Khaliq @UVABME, @UVACancerCenter, we identify actionable epigenetic factors that link single-cell heterogeneity in melanoma differentiation state to MAPK inhibitor sensitivity: https://www.nature.com/articles/s41467-021-21784-2

Mature tertiary lymphoid structures predict immune checkpoint inhibitor efficacy in solid tumors independently of PD-L1 expression | Nature Cancer https://www.nature.com/articles/s43018-021-00232-6

UVA Cancer Center has been awarded a Comprehensive Cancer Center designation effective Feb. 1, 2022, by the National Cancer Institute (NCI), the largest funder of cancer research in the world. @UVACancerCenter #UVA https://newsroom.uvahealth.com/2021/08/27/uva-earns-comprehensive-cancer-center-designation/

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