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Dudley Lab

The Dudley Lab, associated with the Department of Microbiology, Immunology and Cancer Biology (MIC), is focused on the tumor microenvironment and mechanisms of tumor neovascularization. We use transgenic tumor models, in vivo lineage tracing strategies, and endothelial cell cultures to explore differentiation and specialization of the tumor vasculature. We are also focused on how endothelial cells, and other cell types found within the tumor microenvironment such as fibroblasts, contribute to the growth, progression, and immune surveillance of solid tumors and their metastases.

 

DEPARTMENT OF MICROBIOLOGY, IMMUNOLOGY, AND CANCER BIOLOGY
Tumor Blood Vessel

Tumor blood vessel abnormalities

Tumor associated blood vessels have irregular diameters, they are fragile, leaky, and blood flow is abnormal; there is now good evidence that these abnormalities contribute to tumor growth, metastasis, and responses to different therapies.
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Microscopic image of a tumors cell

Tumor blood vessel and tumor microenvironment heterogeneity

Endothelial cells in tumors display a spectrum of responses to TGF beta that underlies the plasticity and dysfunctional features of tumor-associated vasculature.
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Green dye to show the Mechanisms of tumor neovascularization

Mechanisms of tumor neovascularization

Solid tumors have diverse mechanisms for creating new blood vessels or utilizing the pre-existing vasculature to enable their survival.
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University of Virginia/Tumor Microenvironment & Angiogenesis Lab

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DrewDudleyLabDrewDudleyLab@DrewDudleyLab·
6 Jul

Tissue-specific tolerance in fatal Covid-19 | medRxiv. Nice study from my good friend, and favorite Scot, Chris Lucas. https://www.medrxiv.org/content/10.1101/2020.07.02.20145003v1

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alexia_zzAlexia-Ileana Zaromytidou@alexia_zz·
29 Jun

🌟New in @NatureCancer:

@shouval @IdoAmitLab & colleagues chart the dynamic changes of #CAF composition during #BreastCancer progression and link the ratio of two such subpopulations to clinical outcome.

Free access: https://rdcu.be/b5iZS

https://www.nature.com/articles/s43018-020-0082-y

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DrewDudleyLabDrewDudleyLab@DrewDudleyLab·
16 Jun

Tumor Endothelium: The Gatekeepers of Tumor Immune Surveillance

Please join our virtual session at AACR next week! https://www.abstractsonline.com/pp8/#!/9045/session/242

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DrewDudleyLabDrewDudleyLab@DrewDudleyLab·
16 Jun

Reporter mice for isolating and auditing cell type‐specific extracellular vesicles in vivo https://onlinelibrary.wiley.com/doi/full/10.1002/dvg.23369#.XujSkVvBzPM.twitter

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