Dudley Lab

The Dudley Lab, associated with the Department of Microbiology, Immunology and Cancer Biology (MIC), is focused on the tumor microenvironment and mechanisms of tumor neovascularization. We use transgenic tumor models, in vivo lineage tracing strategies, and endothelial cell cultures to explore differentiation and specialization of the tumor vasculature. We are also focused on how endothelial cells, and other cell types found within the tumor microenvironment such as fibroblasts, contribute to the growth, progression, and immune surveillance of solid tumors and their metastases.


Tumor blood vessel abnormalities

Tumor associated blood vessels have irregular diameters, they are fragile, leaky, and blood flow is abnormal; there is now good evidence that these abnormalities contribute to tumor growth, metastasis, and responses to different therapies.
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Tumor blood vessel and tumor microenvironment heterogeneity

Endothelial cells in tumors display a spectrum of responses to TGF beta that underlies the plasticity and dysfunctional features of tumor-associated vasculature.
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Mechanisms of tumor neovascularization

Solid tumors have diverse mechanisms for creating new blood vessels or utilizing the pre-existing vasculature to enable their survival.
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Connect with Dudley Lab

Twitter Feed

Submission deadline for the #EVs in Cancer meeting is 13 May @IsevOrg 2-4 August, 2019 in #Nashville, USA https://t.co/sjvhOW9j2X

A huge congrats to Dr. Andrew Dudley on receiving an MRA Pilot Award to #research Blood Vessel Co-Option by Brain Tropic Melanoma Cells! @MedicineUVA #science #curemelanoma #melanoma https://t.co/rGs0cOxLj0 #MelanomaAwarenessMonth

Interesting paper from Eli Keshet’s lab (Jerusalem) in Cell Metabolism establishing the metabolic zonation of tumor cells around intratumoral blood vessels (histologically called perivascular cuffs): https://t.co/8W1MxOwUmt

Researchers at the UVA School of Medicine have shed light on how cancers hijack the body’s natural wound-healing response to grow and spread. https://t.co/tUXzQhUcBg

On April’s cover: miR-30c represses fibrin-mediated tumor angiogenesis https://t.co/UExQ861KM9 @UVACancerCenter @UNC_CBP #oncology #vascularbiology

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