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Dudley Lab

The Dudley Lab, associated with the Department of Microbiology, Immunology and Cancer Biology (MIC), is focused on the tumor microenvironment and mechanisms of tumor neovascularization. We use transgenic tumor models, in vivo lineage tracing strategies, and endothelial cell cultures to explore differentiation and specialization of the tumor vasculature. We are also focused on how endothelial cells, and other cell types found within the tumor microenvironment such as fibroblasts, contribute to the growth, progression, and immune surveillance of solid tumors and their metastases.

 

DEPARTMENT OF MICROBIOLOGY, IMMUNOLOGY, AND CANCER BIOLOGY
Tumor Blood Vessel

Tumor blood vessel abnormalities

Tumor associated blood vessels have irregular diameters, they are fragile, leaky, and blood flow is abnormal; there is now good evidence that these abnormalities contribute to tumor growth, metastasis, and responses to different therapies.
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Microscopic image of a tumors cell

Tumor blood vessel and tumor microenvironment heterogeneity

Endothelial cells in tumors display a spectrum of responses to TGF beta that underlies the plasticity and dysfunctional features of tumor-associated vasculature.
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Green dye to show the Mechanisms of tumor neovascularization

Mechanisms of tumor neovascularization

Solid tumors have diverse mechanisms for creating new blood vessels or utilizing the pre-existing vasculature to enable their survival.
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University of Virginia/Tumor Microenvironment & Angiogenesis Lab

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BCHArchivesBCH Archives@BCHArchives·
24 Feb

Today we remember Dr. Judah Folkman, @BostonChildrens surgeon, scientist & @harvardmed professor who founded the field of anigogenesis research, born #OTD in 1933. Now, drugs that block angiogenesis- the growth of new blood vessels- prolong life for cancer patients.

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LabMassagueMassagueLab@LabMassague·
12 Feb

RT
Shape-shifting stem cells may sound like science fiction, but
@LabMassague and others have found that it’s the key to cancer #metastasis. Read more about the @NatureMedicine
study from Dr. Joan Massagué, @LaughneyLab, @dana_peer, and @charlesrudin.

https://www.mskcc.org/blog/shape-shifting-stem-cells-are-key-cancer-metastasis-and-immune-evasion?utm_source=Twitter&utm_medium=Organic&utm_campaign=021020DevelopmentalPlasticity&utm_content=Research

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valientelabManuel Valiente@valientelab·
12 Feb

Our review on vascular co-option in #brainmetastasis is out. Special issue edited by @DrewDudleyLab discussing this alternative mechanism that cancer cells use to interact with vessels. No angiogenesis involved. @SpringerNature @CNIO_Cancer
https://link.springer.com/journal/10456 #springerlink

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UVA_MICUVA-MIC@UVA_MIC·
6 Feb

We are seeking applicants with a research focus in cancer biology for a tenure-eligible position at the rank of Assistant/Associate Professor! Apply here: https://uva.wd1.myworkdayjobs.com/en-US/UVAJobs/job/Charlottesville-VA/Cancer-Biologist--Assistant-or-Associate-Professor_R0013925

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jclinicalinvestJournal of Clinical Investigation@jclinicalinvest·
5 Feb

Restoring anti-tumor immune response in Apc-mutant colorectal tumors https://buff.ly/3831QI7 @CHUVLausanne @Ludwig_Cancer #gastroenterology #oncology #angiogenesis

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