Dudley Lab

The Dudley Lab, associated with the Department of Microbiology, Immunology and Cancer Biology (MIC), is focused on the tumor microenvironment and mechanisms of tumor neovascularization. We use transgenic tumor models, in vivo lineage tracing strategies, and endothelial cell cultures to explore differentiation and specialization of the tumor vasculature. We are also focused on how endothelial cells, and other cell types found within the tumor microenvironment such as fibroblasts, contribute to the growth, progression, and immune surveillance of solid tumors and their metastases.

 

Tumor Blood Vessel

Tumor blood vessel abnormalities

Tumor associated blood vessels have irregular diameters, they are fragile, leaky, and blood flow is abnormal; there is now good evidence that these abnormalities contribute to tumor growth, metastasis, and responses to different therapies.
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Microscopic image of a tumors cell

Tumor blood vessel and tumor microenvironment heterogeneity

Endothelial cells in tumors display a spectrum of responses to TGF beta that underlies the plasticity and dysfunctional features of tumor-associated vasculature.
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Green dye to show the Mechanisms of tumor neovascularization

Mechanisms of tumor neovascularization

Solid tumors have diverse mechanisms for creating new blood vessels or utilizing the pre-existing vasculature to enable their survival.
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Connect with Dudley Lab

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Long awaited, published today in Cancer Cell: Comparative single cell RNA-seq analysis of normal and tumor angiogenic mouse and human lung endothelial cells – enormous piece of work (4 first authors, 3 senior authors, 48 authors total) – an incredible resource for further study

Insights on the biology of primary brain tumors and metastases from @NatureRevCancer 🧠 https://www.nature.com/articles/s41568-019-0232-7

Preprint of our ‘Perspectives’ article “Beyond angiogenesis: Exploiting angiocrine factors to restrict tumor progression and metastasis” published in Cancer Research today (https://cancerres.aacrjournals.org/content/early/2019/12/12/0008-5472.CAN-19-3351). Worth reading food-for-thought if you care about the tumor microenvironment.

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