Dudley Lab

The Dudley Lab, associated with the Department of Microbiology, Immunology and Cancer Biology (MIC), is focused on the tumor microenvironment and mechanisms of tumor neovascularization. We use transgenic tumor models, in vivo lineage tracing strategies, and endothelial cell cultures to explore differentiation and specialization of the tumor vasculature. We are also focused on how endothelial cells, and other cell types found within the tumor microenvironment such as fibroblasts, contribute to the growth, progression, and immune surveillance of solid tumors and their metastases.

 

Tumor Blood Vessel

Tumor blood vessel abnormalities

Tumor associated blood vessels have irregular diameters, they are fragile, leaky, and blood flow is abnormal; there is now good evidence that these abnormalities contribute to tumor growth, metastasis, and responses to different therapies.
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Microscopic image of a tumors cell

Tumor blood vessel and tumor microenvironment heterogeneity

Endothelial cells in tumors display a spectrum of responses to TGF beta that underlies the plasticity and dysfunctional features of tumor-associated vasculature.
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Green dye to show the Mechanisms of tumor neovascularization

Mechanisms of tumor neovascularization

Solid tumors have diverse mechanisms for creating new blood vessels or utilizing the pre-existing vasculature to enable their survival.
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Connect with Dudley Lab

Twitter Feed

I’m very happy to share our study that identifies a new immunoregulatory subtype of dermal lymphatic endothelial cells – iLECs! Read the key findings below.
https://www.biorxiv.org/content/10.1101/2022.05.22.492950v1

Periostin+ stromal cells guide lymphovascular invasion by cancer cells https://www.biorxiv.org/content/10.1101/2022.05.19.492742v1

Tumors spread to lymph nodes before they metastasize to distant tissues, but for over a century scientists have debated whether this matters. It does. Check out our paper online now @CellCellPress @CellPressNews
https://www.cell.com/cell/fulltext/S0092-8674(22)00466-4#.YnVBI9O-0_0.twitter

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If you are interested in apCAFs in PDA give this paper from Huocong Huang a read. @utswcancer @UTSWCancerBio @UTSW_Surgery He had wonderful help from @TurleyLabGNE Mesothelial cell-derived antigen-presenting cancer-associated fibrobla... https://www.sciencedirect.com/science/article/pii/S1535610822001738

PAPER ALERT! 🙂
Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures -
https://www.nature.com/articles/s41467-022-29701-x
https://rdcu.be/cLIL1 out today in @NatureComms .
Thank you to all coauthors!

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