Dudley Lab

The Dudley Lab, associated with the Department of Microbiology, Immunology and Cancer Biology (MIC), is focused on the tumor microenvironment and mechanisms of tumor neovascularization. We use transgenic tumor models, in vivo lineage tracing strategies, and endothelial cell cultures to explore differentiation and specialization of the tumor vasculature. We are also focused on how endothelial cells, and other cell types found within the tumor microenvironment such as fibroblasts, contribute to the growth, progression, and immune surveillance of solid tumors and their metastases.

 

Tumor Blood Vessel

Tumor blood vessel abnormalities

Tumor associated blood vessels have irregular diameters, they are fragile, leaky, and blood flow is abnormal; there is now good evidence that these abnormalities contribute to tumor growth, metastasis, and responses to different therapies.
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Microscopic image of a tumors cell

Tumor blood vessel and tumor microenvironment heterogeneity

Endothelial cells in tumors display a spectrum of responses to TGF beta that underlies the plasticity and dysfunctional features of tumor-associated vasculature.
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Green dye to show the Mechanisms of tumor neovascularization

Mechanisms of tumor neovascularization

Solid tumors have diverse mechanisms for creating new blood vessels or utilizing the pre-existing vasculature to enable their survival.
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Connect with Dudley Lab

Twitter Feed

Tumor vascular normalization improves cancer immunotherapy that, in turn, improves tumor vascular normalization: an innovative paradigm of immune system–tumor vasculature mutual reprogramming is emerging.

#Cancer
#VascularNormalization
#Immunotherapy

https://t.co/66zpe6aiPD

Great study from @DrewDudleyLab | A miRNA signature in endothelial cell-derived extracellular vesicles in tumor-bearing mice. https://t.co/hzkwwEP4kb

Pls RT- @ParkLabUVA seeks a postdoc for exciting projects on new drivers of #SCLC. Welcome anyone interested in cancer metabolism and microenvironment! Ask your student to send cv to kp5an@virginia.edu.

The potential for human #organoids in medicine is growing, along with a blood supply
https://t.co/L9d1UvmZQX
@NatureMedicine by @KarunaMDPhD and colleagues
https://t.co/nt9eBmoRqJ
@naturemethods by @IHPark5 @YaleGenetics et al

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Could tiny bits of RNA help to stop a #tumor in its tracks? A recent study suggests it’s possible. Take a look. #NIH https://t.co/KanpBV5dks

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