Dudley Lab

The Dudley Lab, associated with the Department of Microbiology, Immunology and Cancer Biology (MIC), is focused on the tumor microenvironment and mechanisms of tumor neovascularization. We use transgenic tumor models, in vivo lineage tracing strategies, and endothelial cell cultures to explore differentiation and specialization of the tumor vasculature. We are also focused on how endothelial cells, and other cell types found within the tumor microenvironment such as fibroblasts, contribute to the growth, progression, and immune surveillance of solid tumors and their metastases.

 

Tumor Blood Vessel

Tumor blood vessel abnormalities

Tumor associated blood vessels have irregular diameters, they are fragile, leaky, and blood flow is abnormal; there is now good evidence that these abnormalities contribute to tumor growth, metastasis, and responses to different therapies.

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Microscopic image of a tumors cell

Tumor blood vessel and tumor microenvironment heterogeneity

Endothelial cells in tumors display a spectrum of responses to TGF beta that underlies the plasticity and dysfunctional features of tumor-associated vasculature.

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Green dye to show the Mechanisms of tumor neovascularization

Mechanisms of tumor neovascularization

Solid tumors have diverse mechanisms for creating new blood vessels or utilizing the pre-existing vasculature to enable their survival.

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Twitter Feed

I'm SO EXCITED to share our new pre-print! 🥳
You finally got your RNA-seq data. You open RStudio, stare at the screen for 5 mins...And realize you don't even remember how to import a table. How will you analyze your data?!😱We're here to help! A 🧵👇(1/9) https://www.biorxiv.org/content/10.1101/2022.11.25.517851v1

Very excited to share our new research paper in @Cancer_Cell on tumor HEV's! Congrats @gerlanda_vella and Yichao Hua!

@vib_ccb @Onco_KULeuven @VIBLifeSciences

https://www.cell.com/cancer-cell/fulltext/S1535-6108(22)00549-9

And it’s online, I’m very proud to share that our paper on neutrophil transendothelial migration hotspots can be found online @EMBOreports!

https://www.embopress.org/doi/full/10.15252/embr.202255483

Here is a short summary detailing our major findings:

1/9

Check out our latest article, where postdoc Zhenpeng (Jason) Wan, graduate student Marie Floryan, and team show a new method to vascularize tumor spheroids-on-chip! https://onlinelibrary.wiley.com/doi/10.1002/adhm.202201784#.Y3QhDRFAtVA.twitter

Pan-cancer single-cell analysis reveals the heterogeneity and plasticity of cancer-associated fibroblasts in the tumor microenvironment
https://www.nature.com/articles/s41467-022-34395-2#MOESM2
A dozen publicly available scRNA seq datasets were collated for this study. CAF Browser at:
https://gist-fgl.github.io/sc-caf-atlas/

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