Dudley Lab

The Dudley Lab, associated with the Department of Microbiology, Immunology and Cancer Biology (MIC), is focused on the tumor microenvironment and mechanisms of tumor neovascularization. We use transgenic tumor models, in vivo lineage tracing strategies, and endothelial cell cultures to explore differentiation and specialization of the tumor vasculature. We are also focused on how endothelial cells, and other cell types found within the tumor microenvironment such as fibroblasts, contribute to the growth, progression, and immune surveillance of solid tumors and their metastases.

 

Tumor blood vessel abnormalities

Tumor associated blood vessels have irregular diameters, they are fragile, leaky, and blood flow is abnormal; there is now good evidence that these abnormalities contribute to tumor growth, metastasis, and responses to different therapies.
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Tumor blood vessel and tumor microenvironment heterogeneity

Endothelial cells in tumors display a spectrum of responses to TGF beta that underlies the plasticity and dysfunctional features of tumor-associated vasculature.
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Mechanisms of tumor neovascularization

Solid tumors have diverse mechanisms for creating new blood vessels or utilizing the pre-existing vasculature to enable their survival.
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Connect with Dudley Lab

Twitter Feed

Honored to learn @uvahealthnews VA Board of Visitors voted to rename the UVA Medical Center West Complex as the Collins Wing! As a proud alum I hope those who pass through are encouraged by the care, compassion&healing that lives within those walls. #NIH https://t.co/qKolBeWqVM

Let’s play a little game.

Let’s say that you’re the CSO at a cancer pharma company, and you have to choose a target to go after.

Here’s a gene – high expression is associated with poor prognosis in brain cancer. Looks like a good candidate for an inhibitor right?

SAVE THE DATE! Don’t miss the first EVs and Cancer meeting of ISEV @IsevOrg @doldivizio and the MRS @MetastasisRS @A_Zijlstra. There is a fantastic lineup of speakers. Please register here: https://t.co/nDgnf8s8Az

Submission deadline for the #EVs in Cancer meeting is 13 May @IsevOrg 2-4 August, 2019 in #Nashville, USA https://t.co/sjvhOW9j2X

A huge congrats to Dr. Andrew Dudley on receiving an MRA Pilot Award to #research Blood Vessel Co-Option by Brain Tropic Melanoma Cells! @MedicineUVA #science #curemelanoma #melanoma https://t.co/rGs0cOxLj0 #MelanomaAwarenessMonth

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