Welcome to the Cliffe Lab

 Herpes simplex virus infection of neurons

The Cliffe lab investigates the mechanism of herpes simplex virus (HSV) latency and reactivation in neurons. We use primary and differentiated neurons along with in vivo models to determine why HSV establishes a latent infection only in neurons and how the virus reactivates under conditions of cell stress. Our goals are to understand 1) how neurons sense and respond to HSV infection, 2) the mechanisms by which HSV gene silencing occurs in neurons and 3) how gene silencing is reversed during reactivation.

 

HSV establishes a latent infection in neurons, during which the viral genome associates with silent heterochromatin. Following a reactivation stimuli, the chromatin is remodelled to allow viral gene expression to occur.

HSV establishes a latent infection in neurons, during which the viral genome associates with silent heterochromatin. Following a reactivation stimuli, the chromatin is remodelled to allow viral gene expression to occur.