Park Laboratory discovering ways to halt small cell lung cancer

“An unexpected discovery at University of Virginia Cancer Center has allowed scientists to halt the development of small-cell lung cancer in lab mice, and the surprise finding could open the door to a new treatment approach in people.

The researchers, led by UVA’s Kwon-Sik Park and John H. Bushweller, were seeking to understand the role of a mutation in the EP300 gene in the formation of small-cell lung cancer tumors. Their experiments revealed that the gene makes a protein with surprising properties that can both foster or prevent the development of small-cell lung cancer. By preventing the gene from acting as a tumor-promoter, the researchers were able to stop the cancer from forming and spreading. This held true in both cell samples and lab mice.” [Read the complete article in UVA TODAY]