Hervé Agaisse, PhD
Hervé received his PhD at the Pasteur Institute in Paris working on the regulation of toxin gene expression in the entomopathogen Bacillus thuriengiensis. He conducted his post-doctoral training at the Harvard Medical School studying the innate immune response to bacterial infection in Drosophila melonogaster and developed high-throughput RNAi-based genomic approaches for identifying host genes supporting intracellular infection. He started his laboratory in 2005 at Yale University where his group applied the RNAi methodology combined with high-throughput microscopy to systematically identify host genes supporting the dissemination of intracellular pathogens, including Listeria monocytogenes, Shigella flexneri and vaccinia virus. Hervé joined UVa in 2015 where he is currently conducting a research program centered on the molecular and cellular mechanisms supporting Shigella flexneri infection in tissue culture systems and newly developed small-animal models of Bacillary dysentery.